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Imatinib-induced protection against beta-cell death
Sweden (IFMSA-Sweden) - Uppsala Universtitet, Uppsala
Department Of Medical Cell Biology
Type of Research Project
- Basic science
What is the background of the project?
We have previously made observations that the tyrosine kinase inhibitor imatinib, protects against beta-cell death, and does this both in vitro and in vivo. This protection may underlie the anti-diabetic effects of imatinib which has been observed in animal models and as well as in humans. The mechanisms that mediate this effect, however, are yet not clear. If a better understanding of beta-cell survival is achieved through further research, the obtained results could be used as help in generating novel therapies in Type 1 and Type 2 diabetes.
What is the aim of the project?
To characterize imatinib-induced signaling events that lead to beta-cell protection.
What techniques and methods are used?
The methods that will be used are; an in vitro culture of beta-cells and the beta-cells will then be analysed with microscopy. Flow cytometry and immunoblotting will be used for further analysis. Flow cytometry is used to detect the physical och chemical characteristics of the cells from the culture, and immunoblotting allows visualisation of protein levels from the extract (the proteins will first be denatured and then gel electrophoresis will follow where the electrophoresis membrane will be washed with antibodies).
What is the role of the student?
- The student will mainly observe
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will have the opportunity to try some of the techniques, and will be doing this by participating in the analysis of beta-cells which will be conducted by microscope. The student will also be doing this by participating when it comes to the other metodes that will be used during the research, such as the flow cytometry, which will also contribute to the analysis of the cells and as well as by taking part in the immunoblotting that will be conducted.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Tyrosine kinase inhibitors as novel drugs for the treatment of diabetes. Patricia o Prada and Mario JA Saad. Expert Opin Investig Drugs. 2013 Jun;22(6):751-63. doi: 10.1517/13543784.2013.802768.
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