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Studying the physico-chemical properties of cosmetic products for baths of basic external therapy of atopic dermatitis
Russian Federation (HCCM Russia) - Ural State Medical Academy, Ekaterinburg
Department of Dermatoveneorology and Life Safty, Clinical base: Multidisciplinary clinical medical center "Bonum".
Ufimtseva M.A. MD
Ufimtseva M.A., Sorokina K.S., Alferova A.A., Beresneva T.A., Khorovodnikov I.V.
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Atopic dermatitis is the skin condition, appearing mainly in children, which is an inflammation of the skin accompanied with erythema and itching. In addition, atopic skin is highly prone to dryness, so moisturizing emollients are mostly recommended to the patients. Hydrotherapy is one of the basic methods of treatment widely used in the system of natural medicine, which is also called as water therapy, aquatic therapy, pool therapy, and balneotherapy. The emollients used with water therapy can react on the properties of water and have different effectiveness thought. The study of changes in the physicochemical properties of water systems at different concentrations of surfactants, the development of a formulation of the external therapy composition (emollient) for hydrotherapy, which has moisturizing, lipid-replacement and buffering properties, is extremely in demand to help patients.
What is the aim of the project?
To study the physico-chemical properties of cosmetic products for baths of basic external therapy of atopic dermatitis taking into account the type of water used.
What techniques and methods are used?
The study will consist of: 1. Carrying out the effective formulations of cosmetic products (emollients) for hydrotherapy in the complex treatment of patients with atopic. 2. Development of a methodological to analyze the adsorption properties and antioxidant activity of emollients in different types of water 3. The study of changes in the physicochemical properties of aqueous systems at different concentrations surfactants, the development of the formulation of the composition of the means of external therapy (emollient) for hydrotherapy, which has a moisture scrub, lipid-replacement and buffering properties. During the study, the potentiometric method, conductometry, determination of the critical concentration of micelle will be used to study the physicochemical properties of water systems before and after adding emoliente, iodine number is used to determine emollient antioxidant activity, spectrophotometry to assess the degree of stability and dispersion of emollients, to evaluate Adsorptional properties - stalagmometry. Evaluation of the clinical efficacy of emollients for hydrotherapy in the complex treatment of patients with atopic dermatitis will be carried out using the Objective Severity Assessment of Atopic Dermatitis (OSAAD) index (a new method for objectively assessing the severity of atopic dermatitis, taking into account the functional state of the horn barrier of the skin - transepidermal water loss, moisture content of the horny layer, area of affected areas) and scale scorad. All patients give written informed consent to participate in research work. The study was approved by the local ethical committee.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1. Determination of water systems pH 2. Evaluation of the different types of water electrical conductivity 3. Determination of the critical micelle concentration of aqueous surfactant solutions 4. Measurement of cosmetic oils iodine values 5. Performing spectrophotometry 6. Measurement of the surface tension coefficient by the method of detachment of droplets (stalagmometry) 7. Definition and evaluation of OSAAD index and SCORAD index in patients with atopic dermatitis.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The theoretical teaching will be provided by assistant professors of Department of Dermatology and Life Safety including: 2 lectures – each of 2 academic hours 2 seminars – each of 4 academic hours Preliminary readings 4 academic hours.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Literature researching. Patient survey and examination. Subjects passed: chemistry, basic pharmacology (optional). Previous experience with: literature research.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- https://elibrary.ru/item.asp?id=22472938 Modified hydrotherapy in complex treatment of atopic dermatitis in children Sorokina K.N.; Ufimtseva M.A.; Belokonova N.A.; Naronova N.A. Clinical Dermatology and Venereology. 2014. Т. 12. № 4. С. 75-79.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049052/ Mooventhan A; Nivethitha L. Scientific evidence-based effects of hydrotherapy on various systems of the body. N Am J Med Sci. 2014;6(5):199-209.
- https://elibrary.ru/item.asp?id=29238612 Niselova; M. Z.; Bochkarev; Yu. M.; Kazaeva; A. V.; Chernyadiev; S. A.; Ufimtseva; M. A.; Getmanova; A. V.; ... & Khabibulina; M. M. Treatment and prevention of the atopic dermatitis. 2015. BASIC SCIENTIFIC DIRECTIONS. Healthcare of the Russian Federation; 59(3); 40-42.
- https://www.natural-sciences.ru/ru/article/view?id=32867 Malysheva A.; Ryabova O.; Sorokina K.N.; Naronova N.A.; Belokonova N.A. Investigation of the physicochemical properties of aqueous systems of cosmetics // Successes of modern natural science. - 2013. - № 9. - p. 111-112
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776387/ Galli E; Neri I; Ricci G; et al. Consensus Conference on Clinical Management of pediatric Atopic Dermatitis. Ital J Pediatr. 2016;42:26. Published 2016 Mar 2. doi:10.1186/s13052-016-0229-8
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405870/ Salava A; Lauerma A. Role of the skin microbiome in atopic dermatitis. Clin Transl Allergy. 2014;4:33. Published 2014 Oct 17. doi:10.1186/2045-7022-4-33
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