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Evaluation of anti-inflammatory activitiy of Musa Paradisiaca hydro-alcoholic extract
Universidad Ricardo Palma (URP)
Department of Pharmacology, Faculty of Medicine, Ricardo Palma University, Santiago de Surco, Lima , Perú.
Dra. Vilma Herencia
Dra. Vilma Herencia
Type of Research Project
- Basic science
What is the background of the project?
The inflammation has become a cycle of aggression-recovery. When they extend into cells and other normal tissues, they could result in a pathological process and promote the development of a wide variety of diseases. Given this, it is necessary to use anti-inflammatory drugs that can be controlled and limit the harmful consequences of inflammation. Usually among the drugs used are the steroidal and non-stodic anti-inflammatories (NSAIDs). However, the presence of adverse effects derived from the consumption of these drugs has stimulated the search for new safer and more effective anti-inflammatory agents. Currently, medical practice has guided the research searches for new molecules, including those of natural origin.
What is the aim of the project?
Evaluate the anti-inflammatory activity of Musa paradisiaca hydroalcoholic extract against carrageenin-induced inflammation in rats.
What techniques and methods are used?
1) PREPARATION OF HYDROALCOHOLIC EXTRACT 100 grams of Musa x paradisiaca leafs will be used, which will be dried at room temperature for a week. The method used wil be maceration. 2) INDUCTION OF INFLAMMATION The Paw edema model will be used. The edema will be induced by injecting 0.1 mL of 2% carrageenan in physiological saline solution in the plantar aponeurosis of the right hind paw of the rat, causing an inflammatory reaction. 3) MEASUREMENT OF THE ANTI- INFLAMMATORY EFFECT A plethysmometer will be used.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be part of the team in charge of the project and must complete the following tasks under supervision: - Follow the ethical protocols of animal experimentation. - Prepare the biological material, the animals that will be used must go through a period of acclimatization and gain weight to start the experiment. - Prepare the hydroalcoholic extract, the student will follow step by step the instructions of the teacher to obtain the extract. - Induce the Model acute inflammation, known as a paw edema model. - Administer the drugs. - Collect data.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, there will be a week of induction. There will be 3 seminars about the anti-inflammatory medicinal plants in our country, the bibliographic references will be debated and reviewed.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It requires the student to perform teamwork, leadership and management work situations. They must have discipline and able to work under pressure. Empathy and respect with people who do the activity. As well as know biosafety standards in order to work in a laboratory with experimental animals. Subjects passed: physiology Previous experience with: biosafety standards
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Chatterjee P; Chandra S; Dey P; Bhattacharya S. Evaluation of anti-inflammatory effects of green tea and black tea: A comparative in vitro study. J Adv Pharm Technol Res. 2012;3(2):136–8
- Marie-Magdeleine C; Udino L; Philibert L; Bocage B; Archimede H. In vitro effects of Musa x paradisiaca extracts on four developmental stages of Haemonchus contortus. Res Vet Sci. febrary 1; 2014;96(1):127–32.
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