Characterization of infections produced by enterobacteria resistant to third generation cephalosporins in Manizales, Colombia
Colombia (ASCEMCOL) - Universidad de Caldas, Manizales
Infectious Diseases
Investigation center on infectious diseases of Caldas University, Manizales, Colombia. (Av. Paralela Cr 25 #48-57)
Sebastián Hernández Botero
Sebastián Hernández Botero
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes Yes Yes No No
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
The infections produced by enterobacter resistant to the third generation cephalosporins are a therapeutic challenge for the physicians in charge of handling this type of patients. The antimicrobial treatment initially established will depend on the characteristics of the patients that indicate the probability of having an infection by a microorganism with these characteristics; knowledge of the characteristics of patients who have had this type of infection in Manizales, Colombia, will allow emergency medical staff to establish an adequate antibiotic treatment, which will be associated with better outcomes in complications, duration of infection and mortality in people with infections by microorganisms with this pattern of resistance. They will be taken into account patients over 18 years excluding pediatric and neonatal population.
What is the aim of the project?
To describe the sociodemographic and clinical characteristics related to infections by enterobacter resistant to third generation cephalosporins in patients from Manizales, Colombia.
What techniques and methods are used?
-Introduction to the project: the main researcher will make the theoretical and methodological contextualization to the student, using presentations and personalized advice, during the first 3 days of the exchange. - After induction, the student will characterize the sociodemographic, clinical and microbiological conditions of urinary tract infections by Enterobacter and gram-negative bacilli non-fermentors resistant to third-generation cephalosporins in a third-level institution in Manizales for the years 2017- 2018. A descriptive, retrospective and cross-sectional study will be conducted that includes patients older than 18 years with a diagnosis of urinary tract infections with a positive urine culture for third-generation cephalosporin-resistant Enterobacteriaceae reported in the Resistance Group's antibiotic resistance profile Manizales Antimicrobial (GRAM). Sociodemographic variables will be taken; clinics such as high and low urinary symptomatology, vital signs of admission, empirical and directed antibiotic therapy, antibiotic onset time; also microbiological data regarding the isolated bacterium and the sensitivity to the empirical antibiotics supplied. -Participation in academic sessions: cross-trade activity, in which the student must participate in the sessions of the Manizales Antibiotic Resistance Group -GRAM- which are held weekly (activity of an evaluative nature)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
Search in clinical histories where the Exchange student must corroborate the data presented there and the specific microbiological correlations that should be taken into account for the research project. Diligence of the databases where the student must record the necessary elements to carry out the investigation. Perform an exposition per week to the research group where it will review topics of antibiotic resistance related to the research that goes on.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Every 1 or 2 days theme reviews will be conducted by the tutor, principal researcher or group of researchers infections, antibiotic use and resistance studies, with previous readings to reinforce learning. They must attend the sessions of the bacterial resistance group of Manizales.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
- The student will prepare an abstract
- The student’s name will be mentioned in a future publication
- The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of pharmacology, microbiology, teamwork, adequate computer management, study skills, communication skills.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- González; L.; & Cortés; J. A. (2013). Revisión sistemática de la resistencia antimicrobiana en enterobacterias en aislamientos intrahospitalarios en Colombia. Biomédica; 34(2).
- Buitrago; E. M.; Hernández; C.; Pallares; C.; Pacheco; R.; Hurtado; K.; & Recalde; M. (2014). Frecuencia de aislamientos microbiológicos y perfil de resistencia bacteriana en 13 clínicas y hospitales de alta complejidad en Santiago de Cali - Colombia. Infectio; 18(1); 3–11.
- Maldonado; N. A.; Múnera; M. I.; López; J. A.; Sierra; P.; Robledo; C. G.; Robledo; J.; & GERMEN; G. (2014). Tendencias de la resistencia a antibióticos en Medellín y municipios del Área Metropolitana entre 2007-2012: resultados de seis años de vigilancia. Biomédica; 34(3).
- L.E. Silva; et al. Características y factores de riesgo de la infección de vías urinarias con cultivo positivo para betalactamasas de espectro extendido en adultos atendidos en urgencias en el Hospital Militar Central. Infectio 2018; 22(3): 147-152