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Changes of glucose metabolism in multiple sclerosis – role in pathogenesis and treatment
Slovakia (SloMSA) - Slovak Medical University, Bratislava
Institute of pathological physiology, Faculty of Medicine, Slovak Medical University
Miroslav Vlček, Adela Penesová, Žofia Rádiková
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. It is one of the most common neurological diseases that often lead to patient disability. Its pathogenesis involves an inflammatory and vascular component; however, the role of metabolic changes (mainly glucose metabolism) in the neurodegenerative process has been investigated recently. Studies have shown the presence of insulin resistance in multiple sclerosis patients, which may also contribute to the development of neurodegeneration, but its cause is still not elucidated.
What is the aim of the project?
The main focus of the work will be determination of the possible causes of insulin resistance as well as study of its effect on the immune cells function in patients with multiple sclerosis.
What techniques and methods are used?
The parameters of carbohydrate metabolism, mitochondrial function, endothelial function, autonomic nervous system function, and immune cell reactivity will be determined to achieve the goal. Patients’ data will be compared with those of healthy controls. Methods used: Clinical examinations of the patients and healthy controls targeted to assess: - glucose metabolism – oral glucose tolerance test - measurement of energy metabolism – indirect calorimetry - autonomic nervous system function – heart rate variability, baroreflex sensitivity - endothelial function – post-occlussive hyperemia Analysis of biochemical parameters and hormones in Plasma and serum samples (biochemistry, enzyme linked immunosorbent assays (ELISA), multiplex assays). Analysis of signals from electrocardiography (ECG) and continuous blood pressure measurement. Statistical evaluation of the results (descriptive statistics, t- test, nonparametric test, analysis of variance, correlations). Graphical presentation of the data.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
To observe clinical examinations of patients / healthy controls. Participate in sample analysis – preparation of samples, immunological methods for assessment of hormones (ELISA, multiplex), obtaining the results. To perform analysis of ECG and blood pressure recordings with analytical software (heart rate variability, baroreflex sensitivity). Data analysis, statistical evaluation of the results in statistical software. Preparation of scientific output – graphs and tables preparation, creation of report (if applicable).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of laboratory work (biochemistry, immunology) Work with PC (text editor, spreadsheet software – basic calculations)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Hyperinsulinemia in newly diagnosed patients with multiple sclerosis. Penesova A; Vlcek M; Imrich R; Vernerova L; Marko A; Meskova M; Grunnerova L; Turcani P; Jezova D; Kollar B. Metab Brain Dis. 2015 Aug;30(4):895-901. doi: 10.1007/s11011-015-9665-1. Autonomic Nervous System Response to Stressors in Newly Diagnosed Patients with Multiple Sclerosis. Vlcek M; Penesova A; Imrich R; Meskova M; Mravcova M; Grunnerova L; Garafova A; Sivakova M; Turcani P; Kollar B; Jezova D. Cell Mol Neurobiol. 2018 Jan;38(1):363-370. doi: 10.1007/s10571-017- 0511-3. Nutritional intervention as an essential part of multiple sclerosis treatment? Penesová A; Dean Z; Kollár B; Havranová A; Imrich R; Vlček M; Rádiková Ž. Physiol Res. 2018 Aug 16;67(4):521-533.
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