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Epithelial progenitor cell and the pathogenesis of cerebral malaria: Early detection of Cerebral malaria
Ghana (FGMSA) - University of Ghana Medical School
Noguchi memorial institute for medical research, University of Ghana, Legon
Prof Ben Gyan
Prof Ben Gyan
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The emergence and spread of Plasmodium falciparum resistance to commonly used antimalarials such as chloroquine and sulphadoxine/ pyrimethamine poses major challenges to malaria control in sub-Saharan Africa. We undertook a study on the efficacy of some antimalarial drugs in 2003 with the view of supporting the National Malaria Control Programme in the review of the antimalarial drug treatment policy in Ghana.The artemisinin- based combinations effected rapid fever and parasite clearance. Prevalence of gametocytaemia was highest in the SP group whilst the CHQ group did not show any significant changes in haemoglobin levels during the follow-up period. The findings are in agreement with current recommendations for using artemisinin-based combinations for treating uncomplicated malaria in areas of high CHQ failure such as Ghana. © 2005 Elsevier B.V. All rights reserved.
What is the aim of the project?
● To detect ineffective antimalarial drugs ● To identify potent antimalarial drugs ● To grade the effectiveness of antimalarial drugs
What techniques and methods are used?
Children aged 6-59 months with signs/symptoms of uncomplicated malaria including axillary temperature ≥37.5°C; mono infection with P. falciparum; and parent's willingness to give consent, were randomized into four treatment groups and followed up for a maximum of 28 days. The treatment groups were chloroquine (CHQ), sulphadoxine/pyrimethamine (SP), amodiaquine + artesunate (ADQ + ART) combination, and artemether + lumefantrine (Coartem ®) combination. Clinical evaluation of 168 children studied showed that cumulative pcr-corrected cure rates on day 28 were 100% for ADQ + ART; 97.5% for coartem, 60% for SP and 25% for CHQ. Patients and controlsare recruited. Informed and consented samples are optained and then processing of samples is done using flow cytometry analysis, ELISA, RT-PCR Data entry (clinical information and lab. Results)
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will observe different patients being treated with different antimalarial group. The student will be assisted in to access patient’s progress through monitoring and evaluation using the patients progress report to allow the student to appreciate either a positive progress(better) or otherwise The student will analyse the data and present to the professor charge. The studies will then be carried out at another field and then the results will be compare with the previous field. Rapid diagnostic kits(RDTs), which is a medical diagnostic test designed to suit this study to allow for quick and easy diagnosis, will be used to determine severe malaria ad people with severe malarial will be the sample group.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
YES Lectures will be held first of all on Biosafety measures in the lab. Students would also be invited to attend weekly journal club meetings where past and ongoing projects are assessed and discussed by the entire department.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic lab skills Student will not require any special knowledge or a certain level of studies
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Title: Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana. Author: Koram; K.A.; Abuaku; B.; Duah; N.; Quashie; N. Date: 2005-09
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