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Weight loss independent effects of bariatric surgeries
Israel (FIMS) - Hebrew University, Jerusalem
Dept. of Developmental Biology and Cancer Research
Dr. Danny Ben-Zvi
Dr. Danny Ben-Zvi
English, Spanish, French, Hebrew, Arabic
Type of Research Project
- Basic science
What is the background of the project?
Weight-loss surgeries induce weight-loss and many other dramatic metabolic and endocrine effects, due to malabsorption, restriction in eating and changing the gastrointestinal anatomy. It is generally difficult to distinguish between weight-loss/food restriction effects to those induced by the change in the anatomy. In the lab, we use mouse models, biopsies from patients, mathematical models and bioinformatics to identify physiological effects of the surgery that are independent of weight loss. The student will join a graduate student in the lab studying a specific effect of the surgery on diabetes, fatty liver, neuronal signaling, gastrointestinal homeostasis etc, depending on preference of the student and specific timing.
What is the aim of the project?
The aim of the project is to identify physiological effects of the surgery that are independent of weight loss using different methods such as mouse models, biopsies from patients, mathematical models and bioinformatics.
What techniques and methods are used?
Projects may include some/all techniques: Dissections, tissue collection, Imaging of fixed tissues, expression analysis, methylation analysis, mathematical modeling, Light microscopy, histology, PCR (Polymerase Chain Reaction), Western blotting. Kinds of data analysis we use are data analysis of epigenetic modifications and gene expression data using PCR for example; data analysis of physiological data obtained in the lab.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
There are several possibilities, depending on the background of the student, and her/his interests. These include: Different methods of Imaging of tissues obtained in the project s/he will join, depends on tissue; Quantification of imaging data; Literature search; Data analysis of epigenetic modifications and gene expression data using PCR (Polymerase Chain Reaction) for example; Data analysis of physiological data obtained in the lab. Epidemiological data from national repositories. Skills that will be taught to the student: Light microscopy, histology, PCR, Western blotting, data analysis.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Reading. The student is expected to attend seminars together with other graduate students in the lab and present his/her work in a group seminar
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Reading No animal handling will be expected. Skills that will be taught to the student: Light microscopy, histology, PCR, Western blotting, data analysis. Subjects passed: Histology, Physiology, Endocrinology
Are there any legal limitations in the student’s involvement
Student must obtain insurance.
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields - Dental medicine students (IADS members)
- Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species Ben-Zvi D#; Meoli L; Abidi WM; Nestoridi E; Panciotti C; Castillo E; Pizzaro P; Shirley E; Gourash WF; Thompson CC; Munoz R; Clish CB; Anafi RC; Courcoulas AP; Stylopoulos N#. Cell Metabolism; Aug 7;28(2):310-323.e6 2018
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