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Medical consequences of alcoholism disorder: Impact on systemic inflammation, intestinal permeability and immune activation.
Catalonia (AECS) - Autonomous University of Barcelona (UAB) - Hospital Can Ruti, Barcelona
Internal Medicine – Hospital Germans Trias i Pujol (Can Ruti) Carretera de Canyet, s/n, 08916 Badalona, Barcelona
Daniel Fuster Martí
Daniel Fuster Martí
English (B2) or Spanish
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Alcohol use disorder is common and is associated with a high burden of disease, with an especial impact in young adults. Systemic inflamation, oxydative stress and intestinal permeability are prominent features of the pathogenesis of alcohol-related liver disease. To assess levels of biological markers of intestinal permeability, systemic inflammation and immune activation in patents with alcohol use disorder All these features have been extensively studied not only in animal models but also in patients with liver cirrhosis. All the information collected about those features in patients with alcohol use disorder is related to patients with overt liver disease; because without it, the data collection is scarce.
What is the aim of the project?
To analyze if those features are the link between alcohol use, medical comorbidity and mortality in patients with alcohol use disorders who are admitted for hospital detoxification. To assess the additional impact of cannabis and/ or cocaine consumption in this population.
What techniques and methods are used?
When the patient is admitted in the project, he or she will take part in a clinical exam and we’ll write down his/her medical history. With the clinical exam, we will look for some markers in his/her blood (using: Enzyme-Linked ImmunoSorbent Assay and Cytometric Bead Array techniques) We will compare the results of this markers with their medical history comparing using basic data-analysis to conclude if the clinical and the social niformation take part to determine the markers and the pathology.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student would do a review with clinical charts from the patients and analyze them in order to familiarize with their pathologies. They would entry data into the database. Their main task would be literature search in books, journals, Pubmed, etc. in order to enter the data they find into the database and metanalyze the information they find to elaborate a manuscript. This manuscript draft would be presented to the research team at the end of the internship by the student and it will be supervised and corrected by all the team. Althought the student would be supervised by the research team, he or she will be able to work on their own (methaalisys and Stadistics).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings that would be sent to the student by the LORE. All the programms the student will use in the exchange program would be taught at the beginning of the exchange.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic research skills (such as pubmed management and basic biostatistics) and excel management. Pubmed research skills.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- C Tural; D Fuster; J Tor; I Ojanguren; G Sirera; A Ballesteros; JAJ Lasanta; R Planas; C Rey‐Joly; B Clotet. Time on antiretroviral therapy is a protective factor for liver fibrosis and hepatitis C virus (HCV) co-infected patients. Journal of viral hepatitis. 2003; 10(2):118-125.
- AL Ballesteros; S Franco; D Fuster; R Planas; et al. Early HCV dynamics on Peg-interferon and ribavirin in HIV/HCV co-infections: indications for the investigation of new treatment approaches. Aids. 2004; 18(1):59-66.
- G Navarro; MM Nogueras; F Segura; J Casabona; JM Miro; J Murillas; C Tural; E Ferrer; A Jaén; L Force; J Vilaró; I Garcia; A Masabeu; J Altés; A Esteve; O Sued; M Riera; B Clotet; D Podzamczer; JM Gatell. HIV-1 infected patients older tan 50 years. PISCIS cohort study. Journal of invection. 2008; 57:64-71.
- Muga R; Sanvisens A; Fuster D; et al. Unhealthy alcohol use; HIV infection and risk of liver fibrosis in drug users with Hepatitis C. PLoS One. 2012;7(10):e46810. Fuster D; Sanvisens A; Bolao F; Serra I; Rivas I; Tor J; et al. Impact of hepatitis C virus infection on the risk of death of alcohol-dependent patients. J Viral Hepat. 2014 Aug 18; 10.1111/jvh.12290
- Fuster D; Tsui JI; Cheng DM; Quinn EK; Bridden C; Nunes D; Libman H; Saitz R; Samet JH. Impact of lifetime alcohol use on liver fibrosis in a population of HIV-infected patients with and without hepatitis C coinfection. Alcohol Clin Exp Res. 2013;37:1527–1535
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