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Physiological and immunological responses to different models and intensities of acute and chronic exercise in people living with Human Immunodeficiency Virus
Universidade Estadual de Maringa (UEM)
Physiological Sciences Av: Colombo, 5790, Bloco H-79, room 109. Maringá-PR
SIDNEY BARNABE PERES
SIDNEY BARNABE PERES AND SOLANGE MARTA FRANZÓI DE MORAES
English, Portuguese and Spanish
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Physical training has been used for therapeutic and preventive purposes in a number of pathophysiological conditions, since it modulates the expression of proinflammatory cytokines acting on the neuroimmunoendocrine axis. Different training models, whether of strength or resistance characteristics, have positively modulated body composition, upper and lower limb strength, maximal oxygen uptake and causing reduction of circulating cytokines such as IL6, IL18 and TNFα in HIV+ patients undergoing antiretroviral therapy. The relationship between moderate physical training and the inflammatory profile of people living with HIV / AIDS at the serum level shows that exercise when performed chronically can improve the inflammatory profile caused by the production of cytokines.
What is the aim of the project?
To assess the acute and chronic effects of different physical training models with identification of their ideal intensity in HIV-infected individuals on physiological parameters (blood pressure, heart rate variability) and immunological parameters (pro-and anti-inflammatory markers) and peripheral viral reserves present in the subcutaneous adipose tissue of people living with HIV who use antiretroviral therapy
What techniques and methods are used?
1. Assessment of resting heart rate variability will be performed prior to the training protocol. 2. Determination of plasma cytokines by Bead Immunoassay Multiplex Kit, analyzed on the Luminex - Magpix® 200TR equipment. 3. General biochemical assays: glucose, free fatty acids, among others. 4. Real Time polymerase chain reaction.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be in charge of the interview with the patients which will be overseen by one of the projects responsible, if they’re not capable of speaking Portuguese this part will be skipped. The other task is the withdrawing of blood samples, taking the sample to the laboratory and starting the sequence of tests needed. The student will prepare and apply the laboratory techniques to the samples and after that will analyze the results in the microscope.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Every Thursday we have a theoretical meeting with presentation of seminars and discussion of results.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Be able to work in group, be committed and organized. Subjects passed: Human physiology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- PEDRO; R. E. et al. Exercise improves cytokine profile in HIV-infected people: A randomized clinical trial. Cytokine; v. 99; n. March; p. 18–23; 2017.
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