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CEP-701 (lestaurtinib) as adjusted treatment to abort convulsive status epilepticus and prevent epiletogenesis in the peri-adolescent Kainic acid model of temporal lobe epilepsy
American University of Beirut
Department of Anatomy, cell biology and physiological sciences
Prof. Elie Al Chaar
Dr. Makram Obeid
Type of Research Project
- Basic science
What is the background of the project?
Epilepsy is a disorder in the central nervous system characterized by recurrent seizures (abnormal excessive and hypersynchronous discharges of a population of cortical neurons) provoked by systemic or neurologic insults. Clinically as well as in experimental animal model, epilepsy can be acquired following an initial precipitating brain injury in a process referred to as epileptogenesis and is often accompanied by deleterious cognitive disturbances and psychiatric co-morbidity. These still lack an efficient drug to prevent epileptogenesis such as status epilepticus (thirty minutes of more of continuous or recurrent seizures without recovery to baseline function).
What is the aim of the project?
The aim of the project is to confirm the potential adjuvant role of CEP-701 for use in epilepsy to a standard anti-seizure medications and to dissect its potential mechanism of action.
What techniques and methods are used?
• Conducting stereotactic surgeries • Performing EEG (electroencephalogram) recordings and followed by readings • Performing behavioral testing such as light Dark Box, Forced swim test, Morris Water, open field test, modified active avoidance test. • Conducting Western blot on selected samples • Performing Immunohistochemistry of Immuno-fluorescent staining on selected samples
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will have the opportunity to perform one or more of the behavioral panels mentioned above (light Dark Box, Forced swim test, Morris Water, open field test, modified active avoidance test), as well as he/she will be involved in the analysis of all the behavioral panels. The students will also learn to read EEG (electroencephalogram) and screen for seizures. Moreover the student will have the chance to contribute in book chapters, reviews and manuscript writings
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Obeid; M.; Frank; J.; Medina; M.; Finckbone; V.; Bliss; R.; Bista; B.; ... & Strahlendorf; J. (2010). Neuroprotective effects of leptin following kainic acid-induced status epilepticus. Epilepsy & Behavior; 19(3); 278-283.
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