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Novel biomarkers for the detection of early onset of diabetic nephropathy in type 2 diabetes
American University of Beirut
Department of Anatomy, cell biology and physiological sciences
Prof. Elie Al Chaar
Dr. Assaad Eid
English, French, Arabic
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Diabetes mellitus type 2 is primarily characterized by hyperglycemia and is mainly due to a combination of insulin resistance, inadequate insulin secretion and inappropriate glucagon secretion. Microvascular complications of diabetes include renal, retinal and neuropathic complications. Diabetic nephropathy (DN) represents a serious complication of diabetes and is a leading cause of end stage renal disease (ESRD) and cardiovascular morbidity. Early identification of patients that are prone to develop renal complications is central to better manage and halt the progression of the disease
What is the aim of the project?
Identify a panel of novel putative biomarkers involved in the pathophysiology of diabetic nephropathy and subsequently to investigate their diagnostic and prognostic values in diabetic nephropathy
What techniques and methods are used?
Patients will be recruited and divided into 3 groups whereby: • The first group will be the control • The second will include diabetic patients without nephropathy • The third will include diabetic patients with nephropathy Urine and blood samples will be collected from the study population and tests such as screening for miRNA, Enzyme linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) will be performed
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
As previously mentioned in the method and techniques section after dividing the recruited patients into control, diabetic patients without nephropathy, diabetic patients with nephropathy groups. The student will participate in the collection of samples (mainly urine and blood). Accordingly, the students will help in performing the following experiments: • screening for miRNA • ELISA (Enzyme linked immunosorbent assay) • PCR (polymerase chain reaction)
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, The students will be introduced, by the staff members, to the lab and the project and they will be provided with the proposal and some articles to enhance their understanding about the project
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Lab experience and basic biology knowledge
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Pezzolesi; M. G.; Satake; E.; McDonnell; K. P.; Major; M.; Smiles; A. M.; & Krolewski; A. S. (2015). Circulating TGF-β1-regulated miRNAs and the risk of rapid progression to ESRD in type 1 diabetes. Diabetes; db150116.
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