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The use of gallic acid as treatment of oral squamous cells carcinoma of head and neck
Brazil (IFMSA-Brazil)- Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros
Health Science program
André Luiz Sena Guimaraes
André Luiz Sena Guimaraes
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The gallic acid (GA) is a natural compound found in Brazilian plants, some of them are Allan blackia floribunda, Garcinia densivenia, Bridelia micrantha, Caesalpinia sappan, Dillenia indica, Diospyros cinnabarina, Paratecoma peroba, Psidium guajava, Syzygium cordatum, Rhus typhina, Tamarix nilotica, Vitis vinifera, Hamamelis virginiana, Toona sinensis Oenothera bienni and Rubus suavissimus. It is a phenolic compound. It is chemically known as 3, 4, 5- trihydroxybenzoic acid. The structure of gallic acid has phenolic groups that are a source of readily available hydrogen atoms so that radicals produced can be delocalized over the phenolic structureIt was demonstrated that GA could increase apoptosis in neoplasic cells. There are other functions of the GA: antimicrobial, antimutagenic, antiangiogenic and anti- inflammatory agents besides their use in treating critical diseases like depression, cancer, microbial infections, lipid-related diseases, etc. The current project is trying to investigate the in vivo and in vitro effects of GA. Speciffically GA might induce neoplasia radiossenssivity.
What is the aim of the project?
Identification the effect of GA in head and neck squamous cell carcinoma.
What techniques and methods are used?
The researches use polymerase chain reaction (PCR), Fluorescence Microscopy, histopathology, and immunohistochemistry.This analyses in the lab is relationaded with the quantidad o GA.Then the researches inclued this information in epiinfo and analised with qui schare.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Learn and improve the knowledge about cancer with the tutor and the members of oncology team of our teaching hospital. Furthermore, with supervision, she/he will be able to develop a research about the relationship between the Gallic Acid and the cance, ibecause the studant will observed the research and participated in analyse data which qui square in epiinfo. This is the reason that the studant will learn how use the epiinfo.Moreover The experiments will be performed and if the students had learned how to perform experiments they will do.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There are 2 seminars about the subject ( cancer and GA) with the tutor. Adicionally, the student is able work and study with undergraduates, MS and Ph.D. students to perform one seminar related to the strategies to treat cancer.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge epidemiology, molecular biologic, statistics. Certificate of: English
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Naira Nayeem; Asdaq SMB; Heba Salem;Said AHEl- Alfqy.Gallic Acid: A Promising Lead Molecule for Drug Development.J App Pharm 2016; 8: 213. 8:2; (2016). https://doi.org/10.4172/1920-4159.1000213
- Miranda S. M. Tsang; Delong Jiao;Ben C. L. Chan; Kam- Lun Hon; Ping C. Leung;Clara B. S. Lau;Eric C. W. Wong; Ling Cheng; Carmen K. M. Chan;Christopher W. K. Lam; and Chun K. Wong.Anti-Inflammatory Activities of Pentaherbs Formula; Berberine; Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation.Molecules. 2016 Apr; 21(4): 519.Published online 2016 Apr 20. doi: 10.3390/molecules21040519 PMCID: PMC6274171 PMID: 27104513
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