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Chitosan-collagen scaffold collapse and biodegradation after intraabdominal implantation
Russian Federation (HCCM Russia) - Kursk State Medical University, Kursk
Experimental Surgery and Oncology Laboratory
M. David Naimzada
Type of Research Project
- Basic science
What is the background of the project?
Although Experimental Surgery and Oncology Laboratory (ESOLab) performs wide range of discovery studies, main field of interest is implantology and regenerative medicine research. Biodegradation of absorbable surgical material is an important process to study, while developing new materials and its applications. Such characteristics can be described after in vivo implantation of sample either paravertebrally either intrabdominally. Currently, we have access for chitosan-collagen scaffolds, which could be studied for biodegradation in abdominal intraoperational usage scenario. Also, ESOLab is an important information provider for local manufacturers, routinely testing new samples for efficiency and developing new animal models. Therefore, other scenarios using same material could become subject for exchange’s work.
What is the aim of the project?
To characterize augmented chitosan-collagen scaffold short-term collapse and biodegradation after intraabdominal implantation.
What techniques and methods are used?
1. Basic small laboratory animal (SLA) handling, sedation and anesthesia – performed by student; 2. Laparotomy, surgical modeling, sham operation (if possible), wound closure – performed by student; 3. Dynamic (every 1…3 hours) laparoscopy using clinical 5mm camera – performed by student – qualitative characteristics are to be measured; 4. Micromorphometry (tutor is able to lobby small size histological sample prep, enough for this project) – performed by student – quantitative characteristics are to be measured; 5. Ultrasonography (if possible) – observation– quantitative characteristics are to be measured. 6. Literature review (500-700 words, >20 sources) All resources necessary will be provided by tutor (2 Wistar rats, scaffold samples, surgical materials, vivarium access, microscope and stationary PC access, etc). Data acquired both qualitative and quantitative will be analyzed by student using appropriate basic statistical methods under tutor’s supervision to present characteristics of implant degradation temp and particularities.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Full cycle of scientific project management and execution: literature review, planning, performing experiment, experiment outcome assessment, statistical analysis (mean assessment, variability assessment – Mann-Whitney test), and publication. Expected project outcome: at least one conference paper on English. Experienced everyday supervision is provided. Most of the methods, mentioned above, have to be performed cyclically during experiment (micromorphometry, dynamic laparoscopy, numerical data analysis), so they will be performed by student itself after few repetitions under supervision. Student expected to have appropriate language skills to write academic texts (500-700 words, >20 sources), but support and review will be provided. Student is free to volunteer for other ESOLab’s projects, taking place while exchange. All training required to work in ESOLab will be provided.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Animal handling, general safety, aseptics and antiseptics instructions will be given. Basic biomedical research principles will be explained and its accordance will be supervised.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic surgery techniques: sutures, knots, incision. Writing: Intermediate or equivalent. Subjects passed: Pathology, General Surgery.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Rodríguez-Vázquez; M.; Vega-Ruiz; B.; Ramos-Zúñiga; R.; Saldaña-Koppel; D. A.; & Quiñones-Olvera; L. F. (2015). Chitosan and its potential use as a scaffold for tissue engineering in regenerative medicine. BioMed research international; 2015.
- Park; S. N.; Park; J. C.; Kim; H. O.; Song; M. J.; & Suh; H. (2002). Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide cross-linking. Biomaterials; 23(4); 1205-1212.
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