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Insights in the Fundamental Research in Molecular and Cellular Pharmacology
Slovenia (SloMSIC) - University of Ljubljana, Ljubljana
Institute of Pharmacology and experimental toxicology
Prof.dr.Mojca Kržan, dr.med.
Prof.dr.Mojca Kržan, dr.med.
Type of Research Project
- Basic science
What is the background of the project?
Please, provide the background of the project (provide information about the project itself) (min. 10 lines, max. 20 lines) The project consists of various studies done in the laboratories of the Institute of Pharmacology and Experimental Toxicology. The project includes the fundamental neurobiological studies in the field of pharmacodynamics-the study of the effects of endogenous substances, drugs and other xenobiotics on individual organs, tissues and cells in the body, and their effect on the functioning of individual organs in physiological, pathological and undergoing conditions. The studies include research of the signaling pathways of the cells and receptor mechanism studies.
What is the aim of the project?
What is the aim of the project? (highly specific. What is the purpose of the research?) To get the basic knowledge about the signaling pathways and receptor binding mechanisms in the plant, animal and human cells, and also to study potential pharmacological agents that can interfere or act as ligands to this specific receptors in the cells. The aim is also to involve students to get the basic knowledge about the methods used in this studies, such as described in the “techniques and methods”.
What techniques and methods are used?
What techniques and methods are used? Mention the steps/stages in this project. (provide examples and avoid abbreviations. Which tools will be used in general in this project) In the studies there will be used various techniques and methods : cell culture preparations, isolation techniques, isolated organ studies, PCR (Polymerase Chain Reaction), HPLC (High-performance liquid chromatography), flow cytometry, Western blot, radioligand binding and uptake studies. In the beginning of the month the student will be asked to do readings about the methods stated above and he/she will observe the mentor how the different machines are used (how to use the PCR, HPLC machines). In the second stage he/she will be able to perform some of the tasks alone under supervision – for example preparing the cell cultures for further analysis. In the final stage she/he will be able to analyse the results from a specific study – for example how to interpret the results of PCR.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student has to start its training by reading the literature related to this project. Also he has to discuss the main ideas and topics with the supervisor before starting to work in the laboratory. Later, the student will be observing the supervisor working in the lab in order to learn the techniques. He will also learn how to use laboratory tools and machines. Leter, the student will be able to perform some techniques on his own under supervision of his mentor. He will learn the basics of PCR, Western blot, isolation techniques, HPLC method or preparing cell cultures. Depending on the month of exchange and phase of the studies he may also be involved in analysis of the data collected. The student may also be asked to make a scientific report or write a summary of his work in the end.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific skills are required. It is expected from the student to have the basic knowledge of cell biology and pharmacology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system - Dental medicine students (IADS members)
- H.P. Rang.The receptor concept: pharmacology's big idea. British Journal of Pharmacology. 2006 Jan; 147(Suppl 1): S9–S16
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