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Telomere length and its relationship with oxidative stress, inflammation, metabolism, physical performance, cognition and quality of life in overweight/obesity Thai subjects
Thailand (IFMSA-Thailand) - Faculty of Medicine, Khon Kaen University, Khon Kaen
Assistant Professor Supaporn Muchimapura
Associate Professor Naruemon Leelayuwat
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Telomeres are deoxyribonucleoprotein located at the end of eukaryotic chromosomes which composes with telomeric protein complex is called shelterin complex to form internal loops are T-loop and D-loop Many factors can induce telomere attrition such as regular cell division, diseases, socioeconomic, married status and mental stress. Telomere length is a biological aging which broadly studies in various aspects. However, the association of telomere length and exercise or physical performance was uncertain. As above explanation, this project will investigate telomere length in normal weight and overweight/obese individuals at young and old ages and the relationship of telomere length to the metabolism, physical performance, cognition and quality of life in sedentary normal weight and overweight/obese individuals.
What is the aim of the project?
This project will investigate telomere length in normal weight and overweight/obese individuals at young and old ages and the relationship of telomere length to the metabolism, physical performance, cognition and quality of life in sedentary normal weight and overweight/obese individuals.
What techniques and methods are used?
1. Leukocyte telomere length will be measured by using Cawthon’s method based on polymerase chain reaction technique. DNA will be extracted with a manually DNA extraction. Telomere length will be measured by the ratio of telomere repeat copy number and the single copy gene copy number. The single copy gene refers to the 36B4 gene, which encodes acidic ribosomal phosphoprotein, and is located on chromosome 12. 2. Blood parameters (glucose, insulin, lipid profiles, C Reactive protein and HbA1c) will be assayed at the Biochemistry laboratory in Srinagarind Hospital, Khon Kaen University. 3. Other blood parameters i.e. malon dialdehyde, vitamin C will be measured by PhD student. 4. Metabolism (substrate utilization, resting energy expenditure), physical performance (aerobic capacity and hand grip strength), cognition and quality of life. 5. The independent t test was used to compare variables between groups. The Pearson correlation between all the variables and TL, and multiple regression analysis with the TL as dependent variable and the other continuous variables (weight, body mass index, age, biochemical variables and substrate utilization) as the independent ones were performed. The significance level used for the tests was set at p < 0.05.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1. The student will work with patients by assisting in measurement of anthropometry, metabolic rate at rest and exercise peak oxygen consumption under supervision of Assoc.Prof.Naruemon Leelayuwat. 2. The student may have opportunity to measure telomere length or other biochemical assays depending on their capacity under supervision of Assoc.Prof.Naruemon Leelayuwat. 3. The student will have opportunity to help analyzing the data. They will help input and do the data analysis supervision of Assoc.Prof.Naruemon Leelayuwat.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will join the seminars and discussion in some topics. There will be some lectures if the student attend during the term that has lectures.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a scientific report - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific skills.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Janyacharoen T; Auvichayapat P; Tsintzas K; Macdonald IA; Leelayuwat N. Effect of gender on fuel utilization during exercise at different intensities in untrained Thai individuals Eur J Appl Physiol. 2009 Aug 28. [Epub ahead of print] DOI 10.1007/s00421-009-1167-6.
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