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(Sibiu) Correlations between blood cell count and type of epilepsy in adult patients.
Romania (FASMR) - "Lucian Blaga" University - Faculty of Medicine, Sibiu
Prof. Dr. Cosmin Mihalache
Lecturer Dr. Cioca Gabriela
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Epilepsy is a chronic disorder characterized by recurrent unprovoked seizures of cerebral origin with motor, sensory of autonomic disturbance with or without loss of consciousness. Accumulating clinical evidence strongly supports the relevance of inflammation in the pathophysiology of human epilepsy. Different common infections can cause recurrent seizures. Inflammatory markers, such as white blood cells, lymphocytes determine the chronic inflammatory process underlying the pathophysiology of intractable epilepsy presenting with frequent seizures.
What is the aim of the project?
To prove the link between chronic inflammation and epilepsy using retrospective clinical studies.
What techniques and methods are used?
Retrospective clinical study which is done on the basis of a clinical research protocol: The data collection will be done according to the research protocol, which will be created in a maximum of two days (6 hours a day) by the incoming students. The protocol will include clear criteria about selection and exclusion of the cases under study and collection of clinical and paraclinical data from the medical history of the subjects. The collected data must be in accordance with the theme of the project. The data of interest with the research will be registered into a database (SPSS database program – version 25; the program used in our research project), and this operation will be done by the incoming student. After the data registration, the student will start calculating the statistics with the use of different functions of the SPSS database program. Examples of such functions include: calculating different types of averages; standard deviation; obtaining the statistical significance (T-Student, ANOVA, Wil-Coxson-Mann-Whitney etc.); comparison and identification of possible relations between the variables (Fischer, chi-squared etc.). The results obtained after the statistical rendition will be interpreted in correlation with the data from international accredited publications that have already been made for topic studied. Bibliographical sources can be acquired by consulting the books, courses and articles from the library of our university, and electronical sources of other accredited international databases (ScienceDirect, Oxford Journals, Proquest Central, SCOPUS, Springerlink etc.) The conclusion will be summarized and will illustrate clearly the results of our study.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student has to: study the international databases (ScienceDirect, Oxford Journals, Proquest Central, SCOPUS, Springerlink etc.) in order to identify the latest research done internationally about our project. actively take part in the elaboration of the medical research protocol. As an exercise, the student will need to write the necessary document for the approval of the project by our local ethics commission for scientific research. The selection of specific keywords, used for the interference of the database, which contains the medical history of our patients. Database construction in SPSS, for the data registration. The student will than register all the necessary data, according to the research protocol. Together with the tutor, the student will realize the statistical analysis of our project data, with the help of different statistical tests. The final conclusion will be elaborated as a written document about the research done (which can be developed afterwards as a scientific report, and later published in our local scientific magazine).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will be instructed at arrival in regard to the principles and protocols of the study. Informal theoretical discussions can be had throughout the program.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
General knowledge of pharmacology. General knowledge of physiopathology. General knowledge of biostatistics (https://www.spss-tutorials.com/basics/).
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Greenwood et al.; Lymphocytes migration into the central nervous system: implication of ICAM-1 signalling at the blood–brain barrier. Vascular Pharmacology; 2011;38; 315–322.
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