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Morphometric characteristics of heart valve apparatus during prenatal ontogenesis.
Kazakhstan (KazMSA) - Semey State Medical University, SSMU, Semey, Kazakhstan
Department of Anatomy and Histology of Semey Medical University, SMU, Semey, Kazakhstan, str. Abay 103.
c.m.s., Associated Professor, Kozhanova Saule Keneshchanovna.
c.m.s., Associate Professor, Kozhanova Saule Keneshchanovna.
English, Russian, Kazakh
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Development of surgical methods for the treatment of congenital and acquired heart diseases raised. That is why interest is increasing in the dynamics studying of volvuli apparatus development in ontogenesis._ Despite the information about the peculiarities of structure and development of the structural elements of the heart in postnatal ontogenesis exist in the medical literature, necessity of detailed studying of dynamic growth and correlation relationship of heart valve apparatus is emerged. It provides information to revealing the relationship between the indicators. The work was performed on 2-3 fetal heart preparations from 20 to 28 week gestation.
What is the aim of the project?
The aim of this project is metric investigation of heart’s bicuspid and tricuspid valve, as well as semilunar valves of the aorta and pulmonary trunk for identifying the congenital heart defects, anatomical defects of the heart and its valve apparatus.
What techniques and methods are used?
Longitudinal and transverse linear sizes of right and left atrioventricular and semilunar valves are identified by method of direct planimetry. 2-3 prepared heart of fetus from 20-28 week of gestation will be measured. Methods. Firstly, atrioventricular and semilunar valves stenosis will examined. A parasternal short-axis view of the aortic valve was obtained with transthoracic two-dimensional echocardiography. Then, Aortic Valve Area was measured directly by planimetry of the inner leaflet edges at the time of maximal opening in early systole. Aortic Valve Area was also measured by planimetry using transesophageal echocardiography, by the continuity equation and by cardiac catheterization (Gorlin formula). Heart of fetus will be found in our department. By using of this, methods we expected to found the effect of the heart and differences with normal heart in metric investigation.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Student will observe the practical experiments but will be highly involved in the measurements and analysis of the results. They will take active part in the practical aspect of it. The student should learn techniques essential for basic anatomy methods, such as direct planimetry. The student should also obtain knowledge about topics in discussion and paper reading. Students should identified the defect of valves by method of direct planimetry. Identify the differences between normal and changed heart valves. The measurements will be done by the methods, which we mentioned above.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Theoretical lecture provided by tutor about theme “Heart valve flaws” (presentation) twice a week.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Be able to obtain digital data using standard methods of variation statistics. The calculation is arithmetic mean, the error of the mean. Be able to use Student's test.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Rogers JH; Bolling SF. The Tricuspid Valve: Current Perspective and Evolving Management of Tricuspid Regurgitation. Circulation. 2009;119:2718–25. 2. Skwarek M; Hreczecha J; Dudziak M; Jerzemowski J; Wilk B; Grzybiak M. The morphometry of the accessory leaflets of the tricuspid valve in a four cuspidal model. Folia Morphol. 2007;66:323–7. 3. Skwarek M; Dudziak M; Hreczecha J; Grzybiak M. The connection between the papillary muscles and leaflets of the tricuspid valve. Folia Morphol. 2006;65:322–8. 4. Skwarek M; Hreczecha J; Gryzbiak M; Kosinski A. Unusual anatomical features of the right atrioventricular valve. Folia Morphol. 2005;64:183–7. 5. Skwarek M; Hreczecha J; Dudziak M; Jerzemowski J; Szpinda M; Grzybiak M. Morphometric features of right atrioventricular orifice in adult human hearts. Folia Morphol. 2008;67:53–7.
- Skwarek M; Hreczecha J; Dudziak M; Jerzemowski J; Wilk B; Grzybiak M. The morphometry of the accessory leaflets of the tricuspid valve in a four cuspidal model. Folia Morphol. 2007;66:323–7.
- Skwarek M; Dudziak M; Hreczecha J; Grzybiak M. The connection between the papillary muscles and leaflets of the tricuspid valve. Folia Morphol. 2006;65:322–8.
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