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[Aguascalientes] The regulatory role of vasopressin, V1a, V1b and V2 Arginine Vasopressin receptor antagonists on immune and cardiovascular systems
Universidad Autonoma de Aguascalientes
Department of Physiology and Pharmacology. Building 202. Lab. Neuroinmunoendocrinology. Basic Sciences Center. Av. Universidad 940. Col. Ciudad Universitaria. Aguascalientes, Aguascalientes. México. CP 20131
Dr. Marin Gerardo Rodriguez
Dr. José Luis Quintanar Stephano, PhD
English and Spanish
Type of Research Project
- Basic science
What is the background of the project?
The arginine vasopressin (AVP) is essential for a wide range of physiological functions, including water reabsorption, cardiovascular homeostasis and hormone secretion. These and other actions of AVP are mediated by at least three distinct receptor subtypes: V1a, V1b, and V2. Although the antidiuretic action of AVP and V2 receptor in renal distal tubules and collecting ducts is well understood, on recent years various studies has shown an increasing understanding of the physiological roles of V1a and V1b receptors. The V1a receptor is originally found in the vascular smooth muscle and the V1b receptor in the anterior pituitary. The role of AVP as a direct immune and cardiovascular regulator (beside the vasoconstrictor without inotropic or chronotopic effect) has not yet been clarified, and more work is needed to assess its involvement in the immunoneuroendocrine network.
What is the aim of the project?
- To study at cell and molecular levels, how AVP and AVP receptor antagonists regulate the immune responses - To study what is the role of AVP on the long term control of the arterial blood pressure
What techniques and methods are used?
We use the rat model for human multiple sclerosis disease; experimental autoimmue encephalomyelitis and the rat human model of rheumatoid arthritis; adjuvant induced arthritis, hypophysectomies, neuroiermediante pituitary lobectomies and anterior pituitary lobectomies in rats, enzyme-linked immunosorbent assay (ELISA) method for assess several immune responses, histology, foot pad inflammation by pletismometry, measurements of indirect and direct arterial blood pressure.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be asked to read articles related to endocrinology making a remark on the general role of vasopressin to have a global vision of the project, he/she will get involved in the development of the project first by observing the basic laboratory and microsurgery skills, then they will need to handle and take care of laboratory animals and basic laboratory equipment, and finally they will learn microsurgery techniques, enzyme-linked immunosorbent assay (ELISA) assays, and basic concepts of the scientific method.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, there will be readings and seminars on general endocrinology, scientific method and physiology of the cardiovascular and immune systems.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- It is very convenient that the student be in at uper level than the second year of medical carrier (have perfect knowledge of basic sciences as inmunology and physiology). - In order to take full advantage of the exchange, it is advisable to have previous experience in the management of animals, especially rats.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Quintanar-Stephano; A.; Kovacs; K.; Berczi; I. (2014). Effects of neurointermediate pituitary lobectomy on humoral and cell-mediated immune responses in the rat. Neuroinmunomodulation. 11; 233-240.
- Quintanar-Stephano; A.; Chavira-Ramírez; R.; Kovacs; K.; Berczi; I. (2015). Neurointermediate pituitary lobectomy decreases the incidence and severity of experimental autoimmune encephalomyelitis in Lewis rats. Journal of Endocrinology. 184;51-58.
- Campos-Rodríguez; R.; Quintanar-Stephano; A.; Jarillo- Luna; R. A.; Oliver-Aguillón; G.; Ventura-Juárez; J.; Rivera- Aguilar; V.; Berczi; I.; Kalman K. (2016). Hypophysectomy and Neurointermediate Pituitary Lobectomy Reduce Serum IgM; IgG and Intestinal IgA Responses to Salmonella enterica serovar typhimurium Infection in Rats. Infection and Immunity. 73(3).
- Quintanar-Stephano A; Abarca-Rojano E; Jarillo-Luna RA; Rivera-Aguilar V; Ventura-Juárez J; Berczi I; Kovacs K; Campos-Rodríguez R. Hypophysectomy and neurointermediate pituitary lobectomy decrease humoral immune responses to T-independent and T-dependent antigens. J Physiol Biochem. 2011; 66:7-13. Epub 2010 Apr 21.
- Andrés Quintanar-Stephano; Alejandro Organista- Esparza; Roberto Chavira-Ramírez; Kalman Kovacs and Istvan Berczi. Effects of neurointermediate pituitary lobectomy and desmopressin on acute experimental autoinmune encephalomyelitis in Lewis rats. Neuroimmunomodulation. 2011; DOI 3305787. Vol. 19; No. 3; 2012. Published online first; 2011. ISSN: 1021-7401
- Fabio Rotondo; Henriett Butz; Luis V. Syro; George M. Yousef; Antonio Di Ieva; Lina M. Restrepo; Andres Quintanar-Stephano; Istvan Berczi; Kalman Kovacs. (2016). Arginine vasopressin (AVP): a review of its historical perspectives;current research and multifunctional role in the hypothalamohypophysial system. Pituitary; Springer Science+Business Media New York 2016. DOI 10.1007/s11102-015-0703-0
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