Projects
Name
Development of new diagnosis and therapies against life-style diseases including cardiovascular and renal disease,diabetes, obesity,hypertension, cancer,etc.
University
Japan (IFMSA-Japan) - Kagawa University, Kagawa
Domain
Pharmacology
Departement
Department of Pharmacology, Kagawa University Medical School 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
Head
Akira Nishiyama
Tutor
Akira Nishiyama
Languages
Required: English Accepted: Japanese
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
yes yes yes No No yes yes yes yes yes yes yes
Type of Research Project
- Basic science
What is the background of the project?
Lifestyle diseases such as diabetes, hypertension, cancer, and cardiovascular and renal diseases are becoming more and more prevalent in Japan and other developed nations. Kagawa in particular has a large population of diabetic patients within Japan. We are investigating pharmacological interventions, especially acting on the kidney and the renin-angiotensin-aldosterone (RAA) system, to aid in diagnosis and therapy of these lifestyle diseases.
What is the aim of the project?
To investigate and record physiological changes within the kidneys during the progression of type 2 diabetes, and to investigate the effects upon and effects from drugs acting on the renin-angiotensin-aldosterone (RAA) system and kidneys (such as SGLT2 inhibitors) during such a progression. We hope this investigation will lead to new diagnostic and therapeutic techniques for diabetes as well as other lifestyle diseases.
What techniques and methods are used?
The general procedure for our kidney experiments involve administering a drug, observing the effects on blood flow in the kidney, and then doing analysis of gene and enzyme expression in the involved area. Blood flow observation is done through both established and new techniques, including doppler, heartrate telemetry, two-photon in vivo imaging, and sympathetic nerve monitoring. Our lab has other research projects progressing simultaneously, so the student will have the opportunity to observe other techniques such as induced pluripotent stem cell culturing.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Our policy is for all investigators, including students, to take responsibility for their own projects. Students will be given a project and will be responsible for researching the project background, proposing a protocol, performing the experiments, and analyzing the data. The exact experiment performed will depend on the student’s proposal but can be expected to involve drug administration to animals and blood flow measurement. Supervisors will guide these experiments and lab technicians will help perform the experiments.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes. We do group readings of articles and provide instruction as needed, as well as biweekly conferences to review and evaluate the progress of ongoing research.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Speaking English or Japanese
Are there any legal limitations in the student’s involvement
No
Hours
7
Type of students accepted
This project accepts:
- Medical students
Articles
- 1. Kitada K; et al. High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation. J Clin Invest. 2017; 127(5): 1944-1959.
- 2. Kouchi M; et al. (Pro)renin receptor is crucial for glioma development via the Wnt/β-catenin signaling pathway. J Neurosurg. 2017; 6: 1-10.
- 3. Miyashita T; et al. Hormonal changes following a low-salt diet in patients with Meniere’s disease. Auris Nasus Larynx.2017; 44(1): 52-57.
- 4. Kobayashi M; et al. The relationship between the renin-angiotensin-aldosterone system and NMDA receptor-mediated signal and the prevention of retinal ganglion cell death. Invest Ophthalmol Vis Sci. 2017; 58(3): 1397-1403.
- 5. Hasan AF; et al. Increase in tumor suppressor Arf compensates gene dysfunction in in vitro aged adipocytes. Biogerontology. 2017; 18(1): 55-68.
- 6. Rahman A; et al. Cardioprotective effects of SGLT2 inhibitors are possibly associated with normalization of circadian rhythm of blood pressure. Hypertens Res. 2017; 40: 535-40.
- 7. Rahman A; et al. Effect of a selective SGLT2 inhibitor; luseogliflozin; on circadian rhythm of sympathetic nervous function and locomotor activities in metabolic syndrome rats. Clin Exp Pharmacol Physiol. 2017; 44(4): 522-525.
- 8. Vazquez-Anaya G; et al. Exogenous thyroxine improves glucose intolerance in insulin-resistant rats. J Endocrinol. 2017;232(3): 501-511.
- 9. Kobayashi R; et al. An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in a chronic kidney disease model. Kidney Int. 2017; 91(5): 1115-1125.