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[Sousse]Study of the life quality of subjects at high risk of psychotic transition, as part of the early screening of psychosis.
Tunisia (ASSOCIA-MED) - University of Sousse/ Faculty of Medecine of Sousse, Sousse
department of mental health- Farhat Hached Teaching Hospital Sousse, ,Avenue 4000 Sousse, Tunisia
Pr.Salma Ben Nasr
Dr Amel Braham
French and/or Arabic (Recommended) / English (Accepted)
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Early detection of psychoses is one of the clinician's current concerns. The importance of such screening lies in the possibility of improving the prognosis of these disorders known by their chronic and disabling evolution. This screening offers the possibility of an early intervention that could guarantee an improvement or even a disappearance of the symptomatology. The observation of prodromes in schizophrenia is old. Kraeplin, already, in 1909 recognizes as prodromal signs of schizophrenia slight changes in emotional life, irritability, loss of interest, hyperactivity and a decline in concentration. However, the nature of this early intervention remains to this day a subject of controversy including the lack of therapeutic consensus. As a result, the studies focus on the evaluation of different aspects of this early phase of the disease in order to identify the various fields of intervention. Among these fields, the quality of life of subjects in the prodromal phase, said to be subjects with an ultra-high risk of psychotic transition (UHR), remains a little explored area.
What is the aim of the project?
the purpose of our study is to 1) To determine if an individual meets the criteria for an ‘At Risk Mental State’. 2) To rule out, or confirm criteria for acute psychosis. 3) To evaluate the quality of life (QOL) of Ultra high risk (UHR)subjects 4) To map a range of psychopathology and functioning factors, over time in young people at ultra high-risk of psychosis
What techniques and methods are used?
This is a descriptive, quantitative study: -The identification of Ultra high risk (UHR) subjects by using the "Comprehensive assessment of at risk mental states" (CAARMS). - The evaluation of the quality of life will be made by the SF 36: The Short Form (36) Health Survey is a 36-item, patient-reported survey of patient health. The SF-36 is a measure of health status and an abbreviated variant of it . - Evaluation of the clinical symptomatology, will be made by: The Brief psychatric rating scale (BPRS) for general psychopathology, the BPRS is a rating scale which a clinician or researcher may use to measure psychiatric symptoms such as depression, anxiety, hallucinations and unusual behaviour. Positive and negative syndrome scale (PANSS) for positive symptoms, PANSS is a medical scale used for measuring symptom severity of patients with schizophrenia. Scale for the assessment of negative symptoms (SANS) which is is a rating scale to measure negative symptoms in schizophrenia. The Hamilton Depression Scale (HAMD-21) is a multiple item questionnaire used to provide an indication of depression, and as a guide to evaluate recovery.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
- They have to learn how to administer psychometric and clinical questionnaire: (Positive and Negative Syndrome Scale - PANSS; Scale of Assessment of Negative Syndrome – SANS; Brief Psychiatric Rating Scale – BPRS; SF 36: The Short Form (36) Health Survey; Comprehensive assessment of at risk mental states" (CAARMS); The Hamilton Depression Scale (HAMD-21) ) - They will work with patients family to fill the forms. - After filling out the questionnaire the results will be discussed with professors.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
- The student must read general reviews and scientific publications on psychosis - No theoretical teaching will be provided.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- Literature search - Previous knowledge of mental disorders Basic statistics is an advantage - Subjects passed: psychiatry , semiology - Certificate of: psychiatry
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- • Early interventions to prevent psychosis: systematic review and meta-analysis; Megan R Stafford; 2013
- • Health-related quality of life among adolescents :a comparison between subjects at ultra – high risk for psychosis and healthy controls; Freya Nitka ; julia Richter; 2016
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