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AUTOMATED FUNCTIONAL SCREENING OF IgGs FOR DIAGNOSTICS OFNEURODEGENERATIVE DISEASES.
Costa Rica (ACEM) - University of Medical Sciences, San José
Biotechnologies and Informatics
National Nanotechnology Laboratory LANOTEC
Dr. José Roberto Vega-Baudrit
Dr. Bernal Sibaja
English and Spanish
Type of Research Project
- Basic science
What is the background of the project?
Development and characterization of experimental cellular models and procedures as diagnostic and prognostic technologies related to neurodegenerative diseases (NDs), defining markup characteristics of the standardized in vitro approach for personalized diagnostic protocols for automated functional screening of IgGs for diagnostics ofneurodegenerative diseases. The project also proposes to study the applications on other neuroinflammation and neurodegenerative conditions.
What is the aim of the project?
The project proposes to the production of an innovative automated multifunctional device for diagnostics of neurodegenerative diseases. The objectives addressed will be: • Development of experimental cellular models and procedures with immunoglobulins (IgGs) from patient sera as diagnostic and prognostic technologies related to neurodegenerative diseases (particularly based on studies of amyotrophic lateral sclerosis - ALS). • Defining mark-up characteristics of the standardized in vitro approach for personalized diagnostic protocols. • Design of a small-scale platform based on automated fluorescence microscopy.
What techniques and methods are used?
Atomic Force Microscopy (AFM) It will be used to obtain nanometer-scale images for the creation of the device. Scanning Electronic Microscopy (SEM). It will be used to render high resolution threedimensional images that provide topography, morphology and composition of the device. Transmission Electronic Microscopy (TEM) It will be used to observe the morphological, compositional and crystallographic information of the samples with the use of energetic electrons. Thermal analysis. It will be used to observe temperature changes Rheology. Study the flow and deformation of materials under applied forces.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Analyze databases with the help of your tutor. The creation of devices using nanotechnology. He will be present at the conferences as it is a collective project with other countries. Analyze temperature changes using Thermal analysis. Analysis and reading of nanometer-scale images for the creation of the device Analyze data through the Transmission Electronic Microscopy (TEM). Makes a final report for its presentation as learned.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, during seminars, lectures and readings.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Dynamism, interest to learn. Complete the assigned work in a timely manner with attention to quality of work. Respect diverse ideas and opinions. Demonstrate academic integrity and honesty. Attend and participate in classes, labs, and seminars, prepared on time.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Gonzalez; R.; Cadiz; V.; Riccardi; K.; Vega-Baudrit; J.; Isomerization of Fatty Acids A Cellular Barrier Mechanism in Nanotechnology? Journal of Nanoscience and Nanotechnology; 17; 1-9; 2017; https://doi:10.1166/jnn.2017.13791
- Solano; V.; Vega-Baudrit; J.; Gold; silver; copper and silicone hybrid nanostructure cytotoxicity; International Journal of Recent Scientific Research. Vol. 8; Issue; 2; pp. 15478-15486; February; 2017; ISSN 0976-3031.
- Calderón; B.; Johnson Monique E.; Montoro Bustos Antonio R.; Murphy Karen E.; Winchester Michael R.; Vega Baudrit José R.; Silver Nanoparticles: Technological Advances; Societal Impacts; and Metrological Challenges; Frontiers in Chemistry; 5 (6); 2017; pp. 1-26. https://doi.org/10.3389/fchem.2017.00006
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