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Preclinical assessment of a novel wound healing treatment for diabetic patients and chemotherapy-treated patients
Israel (FIMS) - Ben Gurion University of the Negev, Beer Sheva
Department of Clinical Biochemistry & Pharmacology Ben-Gurion University of the Negev at Soroka University Medical Center Old Surgery bldg. #12 rm 472 P.O.B. 151 Beer-Sheva 8410105, Israel
Prof. Eli C Lewis
Ronen Schuster PhD
Type of Research Project
- Basic science
What is the background of the project?
Impaired wound healing remains a common, unmet clinical need. This is of particular relevance to diabetic and oncologic patients, where a poorly healing wound often times leads to complications and may even result in amputation of the affected limb. Successful wound healing requires a burst of inflammation at the injury site. At the same time, unchecked inflammation is the hallmark of poorly-healing wounds. Human alpha-1 antitrypsin (AAT) is an endogenous, serum glycoprotein with established anti-inflammatory and tissue protective properties. We have recently demonstrated that AAT is able to accelerate and enhance closure of acute wounds in several preclinical models suggesting it holds potential for treating chronic wounds as well.
What is the aim of the project?
Preclinical assessment of a novel wound healing treatment for diabetic patients and chemotherapy-treated patients.
What techniques and methods are used?
In-vitro, cell monolayer repair and migration assays are used to dissect specific cellular responses. Response to injury-related stimuli is assessed using ELISA (Enzyme-Linked Immunosorbent Assay) and similar assays. In-vivo, excisional wound models are used to evaluate and optimize the therapy. In addition, skin revascularization is evaluated using live fluorescent imaging (IVIS- in vivo imaging system).
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will assist in designing and conducting experiments. Specific duties include: 1. Monitor wound closure rate 2. Perform fluorescent imaging (IVIS) 3. Perform epithelial monolayer repair assays 4. Preform cell migration assays In addition, the student will be required to organize and analyze the acquired data. Finally, the student will assist in drafting and preparing the data for scientific publication.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Online animal care guideline course. Plus reading material, scientific literature: 3-5 review articles.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
There will be non-invasive small animal work involved (using an imaging system). This is the reason we request that the student(s) obtain an online course prior to arriving. Other than that, we require active brainstorming in lab meetings. Subjects passed: Immunology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- 1-antitrypsin therapy for non-deficient individuals: integrating and mitigating cross-pathology inflammatory and immune responses to the injured cell (Internal Medicine Review 2017)
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