Projects
Name
Eye movement disturbance recorded with eye tracker in patients with focal cervical dystonia
University
Croatia (CroMSIC) - Josip Juraj Strossmayer University of Osijek, Osijek
Domain
Neurology
Departement
Department of Neurology, University Hospital Center Osijek
Head
Prof. Silva Butkovic Soldo, M.D., Ph.D
Tutor
Assist. of Professor Svetlana Tomic, M.D., Ph.D.
Languages
English, Croatian, Bosnian, Serbian
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No No Yes No No No No
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Pathology and pathophysiology of dystonia, the third most common movement disorder, are not entirely researched. Later articles suggest miscommunication between the basal ganglia and cerebellar loops, both involved in motor function regulation. Other areas that show pathological response in patients with dystonia are premotor areas, the associative parietal cortex, visual regions and dorsolateral prefrontal cortex which all play a role in normal executive functioning and visual spatial cognition. Main clinical presentation of focal dystonia is abnormal motor function of one body part that caused abnormal position or tremolous movement. This patients also suffer of non-motor symptoms, such as depression, anxiety, sleep disorders, pain and cognitive dysfunction with deficits in executive, attentional or visuospatial functions. The brain circuits for visually guided saccades extend from cerebral cortex to the pons with many other structures involved. Among them are oculomotor loops and cerebellum.
What is the aim of the project?
To determine eye movement abnormalities in patients with focal dystonia and it`s correlation to cognitive dysfunction in order to detect pathophysiology of eye movement (impairment of oculomotor loops and not a cerebellum).
What techniques and methods are used?
Using X eye tracker we would inspect and determine oculomotor pathology by visually guided stimulus in 50 patients diagnosed from different types of focal dystonia. All patients will also complete cognitive testing (Montreal Cognitive Assessment, Trail making test, Visuospatial test,Wisconsin Card Sorting Test, Tower of London Test).
What is the role of the student?
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
Student will be involved in process of recording of eye movement using eye tracker. This system do not need lot of communication between patient and student, so language barriere will not be a problem. Student should seat near the patient and follow if patient performs all testings correctly. We will teach the student how to warn the patient if he/she stopped performing the testing properly. Beside this, student will be allowed to start and stop testing on eye tracker machine.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Student will be asked to read literature about this subject.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No special skills.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles
- Mov Disord. 2017 May;32(5):757-768. doi: 10.1002/mds.26930. Epub 2017 Feb 10. Disruption in cerebellar and basal ganglia networks during a visuospatial task in cervical dystonia
- Annu Rev Neurosci. 2001;24:981-1004. The role of the cerebellum in voluntary eye movements. Robinson FR1; Fuchs AF.
- Tremor Other Hyperkinet Mov (N Y). 2017; 7: 499. Published online 2017 Oct 9. doi: 10.7916/D8Z89QW7 PMCID: PMC5666016 Abnormalities of Eye–Hand Coordination in Patients with Writer’s Cramp: Possible Role of the Cerebellum Ketan Jhunjhunwala;1;2 Raviteja Kotikalapudi;2 Abhishek Lenka;1;2 Kandavel Thennarassu;3 Ravi Yadav;1 Jitender Saini;4 and Pramod Kumar Pal2;*
- Mov Disord. 2017 Oct;32(10):1348-1355. doi: 10.1002/mds.27048. Epub 2017 Jun 19. The cognitive features of idiopathic and DYT1 dystonia. Jahanshahi M1; Torkamani M1