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Assessment of heart rate variability in young hypertensive patients (Azhar University)
Egypt (IFMSA-Egypt) - Azhar University, Cairo
Cardiology department at El-Hussien Teaching Hospital.
Dr. Ehab El-Hanafy
Required: English Accepted: Arabic
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The research is concerned with, - Coronary heart disease(CHD) and cerebrovascular disease(CVD) represent the most common causes of death worldwide. It has been well established that one of the most important causes of CHD and CVD is hypertension. - Childhood hypertension has been thought to be tightly associated with adult hypertension - Heart rate variability(HRV) which is measured as variation in the beat to beat interval is a physiological phenomenon represents one of the most promising markers for cardiac autonomic nerve function. - A large number of studies have demonstrated that HRV is associated with cardiovascular diseases and mortality.
What is the aim of the project?
The aim of the study is to determine the association between Heart Rate Variability (HRV) and hypertension in young patients for proper selection of medical therapy.
What techniques and methods are used?
Clinical examination to rule out secondary causes of hypertension (HTN) and other exclusion criteria. - Blood pressure measurement and grading of HTN according to Joint National Committee Guidelines (JNC8) with stopping medication 1 w prior to study, avoiding coffee and tea during the day of examination and one day before. - Avoiding strenuous physical activity. - Electrocardiography (ECG) - Echocardiogram for assessment of Left Ventricle (LV) function. - Holter monitoring for 24 h with calculation of standard deviation of all normal RR intervals(SDNN) and evaluation of Atrial and ventricular arrhythmia - HRV analysis using the power of low frequency (0.04-0.15 Hz) which reflects the sympathetic effect and the high frequency (0.15-0.40Hz) mediated by parasympathetic effect. - Calculation of Low Frequency/High Frequency(LF/HF) ratio. Which indicate the balance of Sympathetic and parasympathetic activity. - Calculation of RR interval during daytime and nighttime. - Calculation of SDNN and percentage of successive normal sinus RR intervals (PNN 50).
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1- Practice of learned skills: - General and local cardiac examination including - vital Signs - head & neck examination - upper & lower limb examination - abdominal Examination - Blood pressure measurement. - Resting surface 12 leads Electrocardiography (ECG) will be done for all patients. - Echocardiogram observation. - HRV assessment by Holter. 2-collecting patient history and data cross matching and analysis. 3-observation of the doctor and his work with the patients: - Doctor-patient relationship: - Taking patient history and the doctor will translate for the student in case of the patient does not speak English. - Bedside manners
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Seminars There will be seminars to teach theoretical topics to the student according to his/her knowledge.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
1- previous study of cardiology. 2-Good level of English. Cardiology knowledge is required as he will work with the patients and he will works with his own hands.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Chattipakorn N; Incharoen T; Kanlop N; et al. Heart rate variability in myocardial infarction and heart failure. Int J Cardiol. 2007;120(3):289–96. [PubMed].
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