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Co-delivery of dual cancer drugs against acute myeloid leukemia
China (IFMSA-China) - Peking Union Medical College, Beijing
Biophysics and Medical Physics
Type of Research Project
- Basic science
What is the background of the project?
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults and long-term survival rates are as low as 30 - 40% in younger individuals and less than 10% in elderly patients. It is driven by concomitant activation of different signaling molecules. Therefore, combination therapies using multiple therapeutic agents have been proposed to eradicate leukemia cells by exploiting synergistic effects among drugs and to reduce adverse effects. Compared to separate drug administration, co-delivery of multiple drugs in one system has several potential advantages, such as producing better synergistic effects, greatly improving the patient compliance, and accurately controlling the individual dose. It was shown that the combination of cytarabine, anthracycline antibiotics and homoharringtonine was highly effective in adult AML in China, compared with standard induction therapy.
What is the aim of the project?
To prepare co-delivery micelles encapsulated with hydrophobic homoharringtonine (HHT) and doxorubicin (DOX) for the treatment of AML and to explore the anticancer mechanism.
What techniques and methods are used?
1) Preparation of co-delivery micelles by self-assembly with block copolymer. 2) Determination of particle size by dynamical light scattering. 3) The effect of two single free drugs, combination of free drugs and co-delivery micelles on the viability of HL60/A cells will be determined using Cell Count Kit 8. 4) The internalization of free drug or co-delivery micelles into the cells will be quantified using flow cytometry. The the expression of apoptotic proteins will be semiquantitative by western blot
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1) Prepare co-delivery micelles. 2) Determine the particle size. 3) Determine the cytotoxicity of co-delivery micelles to AML cells. 4) Determine the cellular uptake of co-delivery micelles by flow cytometry. Semiquantification the expression of apoptotic proteins by western blot.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings will be provided. In addition, the tutor will discuss and explain in detail about the project that students will be conducting. Students are encouraged to take part in the group meeting and seminars.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Cell culture, flow cytometry, western blot, data analysis
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- Kemp JA; Shim MS; Heo CY; et al. "Combo" nanomedicine: Co-delivery of multi-modal therapeutics for efficient; targeted; and safe cancer therapy. Advanced Drug Delivery Reviews; 2016; 98:3-18.
- Wu X ; Hu Z ; Nizzero S ; et al. Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity. Journal of Controlled Release; 2017:S016836591730901X.
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