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Assessment of anti-PGL-I serology among contacts of leprosy patients in Anápolis-GO, Brazil
Global Health and Neglected Diseases
Medicine school – UniEvangélica UniEvangélica Medicine school, located at Bloco E, Av. Universitária Km 3,5 Cidade Universitária - Anápolis/GO 75083-515 Brazil
João Batista Carrijo
Theory: Dr. Denis Sugita Dra. Aline de Araújo Freitas Research: Dr. Rodrigo Scaliante de Moura Dra. Emerith Mayra Hungria Pinto Fieldwork: Dr. Rodrigo Scaliante de Moura Dr. Marcelo Cecílio Daher Aline Garcia Fernandes Carvalho.
english, spanish, french, portuguese
Type of Research Project
- Global Action Project (GAP)
What is the background of the project?
Leprosy is a disease caused by Mycobacterium leprae , with a chronic evolution. The bacteria show a tropism for superficial nerves and skin, providing interesting characteristics to the disease, in which neural damage is responsible for eventual sequels.A massive amount of studies had shown that individuals living in close proximity to patients are at increased risk to develop leprosy. The IgM antibody (Ab) titer directed against the M.leprae-specific phenolic glycolipid I (PGL-I) correlates with theleprosy patient bacterial load, as demonstrated before. However, it is insufficiently defined whether anti PGL-I antibodies can be utilized as prognostic biomarkers for disease in contacts,specially, in areas where paucibacillary (PB) patients are predominant.
What is the aim of the project?
The incidence of leprosy in Anápolis-GO will be monitored to verify the accomplishment of the main goal of this project, which is to early detect new leprosy cases and stop transmission by early treating these cases.
What techniques and methods are used?
Data will be collected from the index cases using a Leprosy index case form, which will have all information available from the index case in its medical records. All missing information will be filled at fieldwork. The form will contemplate personal and demographic information. Data will also be collected from contacts at fieldwork using a Contact form, which will be attached to the Leprosy index case form with a unique id number. Accordingly, the contact form will contemplate personal, social demographic information on contacts of leprosy index cases. The results of ML Flow tests, physical examination findings and other relevant information will be added to the form. All participants, including leprosy index cases and contacts will sign a consent form declaring that they are informed about and agree to participate of the research. The incidence of leprosy in Anápolis-GO will be monitored to verify the accomplishment of the main goal of this project, which is to early detect new leprosy cases and stop transmission by early treating these cases.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student may perform a training on leprosy diagnosis, provided by the Tutors, when he/she will learn how to identify characteristic skin smears, measure loss of tactile or temperature sensibility, and other suggestive signs and symptoms of leprosy. After training, the student may participate on field campaigns where he/she will perform physical examinations and the rapid test to detect IgM anti- PGL-I Ab. Furthermore he/she may give speeches about leprosy to the participants of the study and answer eventual asked questions. Furthermore, the present study will perform field campaigns, which are going to be great opportunities to clarify people about leprosy.These results could step up the fight against prejudice and stigma and show the importance of early and proper treatment of leprosy patients, which prevents transmission.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, courses and practical training. The complexity of leprosy as a spectral disease with different clinical manifestations. The different systems of leprosy classification (Ridley Jopling, Madrid and WHO operational classification). The immunology of leprosy, including the immunopathogenic role of the different profiles of TCD4 lymphocytes and evasive mechanisms of M. leprae. The student may speak in public or privately with patients during examination, which may be a great learning opportunity.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- http://www.scielo.br/scielo.php?script=sci_artte xt&pid=S0037-86822008000700004
- http://www.scielo.br/pdf/abd/v86n1/en_v86n1a 12.pdf
- http://www.scielo.br/pdf/rsbmt/v41s2/en_v41s2 a08.pdf
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 154748/
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