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Identification of markers of fibrogenesis in alveolar cells in order to identify new therapeutic targets for pulmonary fibrosis
Portugal (PorMSIC) - University of Coimbra, Coimbra
Department of Pneumology – Coimbra University Hospital
Carlos Robalo Cordeiro
Carlos Robalo Cordeiro, Tiago Alfaro, Maria Manuel Donato
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a median survival rate of 3 years and no curative pharmacological therapy. In this project, we are going to collect cells, by bronchoalveolar lavage, from patients with this disease. The cells will be sorted and several markers related to the progression to fibrosis will be studied, mainly in macrophagues cells and lymphocites. These markers will be correlated with the disease progression status in order to assess which ones may serve as new targets.
What is the aim of the project?
The aim is to understand the mechanisms of the evolution to pulmonary fibrosis and to identify new therapeutical targets.
What techniques and methods are used?
The project involves a clinical part in which bronchoscopies and bronchoalveolar lavages will be done and a lab in which the student will do cell sorting, cytometry, ELISA (enzyme-linked immunosorbent assay) and Real time-Polymerase chain reaction. The statistical analysis of data will be mostly based on testing for correlation between marker expression and clinical data such as lug function.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is expected to be part of the clinical and the lab work in the project. Also he or she is expected to obtain skills in the ELISA (Enzyme-Linked Immunosorbent Assay), in the Real time Real time-Polymerase chain reaction and in cytometry techniques in the lab domain. In the clinical domain the student will participate, with supervision, in the bronchoscopy technique.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No skills required. Subjects passed: Physiology
Are there any legal limitations in the student’s involvement
Obliged to confidentiality.
Type of students accepted
This project accepts: - Medical students
- Wim A. Wuyts; Carlo Agostini; Katerina M. Antoniou; Demosthenes Bouros; Rachel C. Chambers; Vincent Cottin; Jim J. Egan; Bart N. Lambrecht; Rik Lories; Helen Parfrey; Antje Prasse; Carlos Robalo-Cordeiro; Eric Verbeken; Johny A. Verschakelen; Athol U. Wells and Geert M. Verleden; The pathogenesis of pulmonary fibrosis: a moving target DOI: 10.1183/09031936.00073012
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