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Translational Neuroscience Research in Pain and Itch
China (IFMSA-China) - Peking Union Medical College, Beijing
Department of Anatomy, Histology and Embryology
Chao Ma, Professor
Chao Ma, Professor
Type of Research Project
- Basic science
What is the background of the project?
Chronic pain and pruritus are major health challenge worldwide but the underlying mechanisms are not clear. We will explore the neural mechanisms of pain and itch using a combination of advanced technologies covering the areas from molecular mechanisms, animal models and human subjects. The research works are conducted in the Anesthesia-Pain Joint Laboratory by a team consisting basic and clinical research scientists. The purpose is to reveal the neural mechanisms of chronic pain and itch and provide potentially novel treatment strategies.
What is the aim of the project?
Reveal the neural mechanisms of chronic pain and itch and provide potentially novel treatment strategies.
What techniques and methods are used?
Animal Behavior, in vivo and in vitro electrophysiology, Western blotting, Realtime RT-PCR (Polymerase chain reaction), Immunohistochemistry, human psychophysiology, functional MRI(Magnetic Resonance Imaging), transgenic mice and rats.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Students will join the research group and participate in the study of neural mechanisms of pain and itch in animal models and/or human subjects. Students will learn basic knowledge and skills in the neurobiology of pain and itch, and will have chance to communicate and collaborate with our graduate and medical students in Peking Union Medical College (PUMC). Students can do a part of experiment by themselves. For example, animal behavioral test, western blotting, Realtime PCR and Immunofluorescence staining.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Participants will be required to join the weekly research seminar in the Anesthesia-Pain Joint Laboratory, that will in the forms of journal club, research progress report and seminar. There will also be a number of invited research lectures as well as the Anatomy, Histology and Embryology, Neuroanatomy, Neurobiology and Neuroscience courses available, provided by our department in the medical school.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of neuroanatomy, neuroscience and basic skills in biology. Skills in small animal handling, PCR, Western Blotting, Immunohistochemistry and electrophysiology preferred but not mandatory.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Jiang H; Shen X; Chen Z; Liu F; Wang T; Xie Y; Ma C*. Nociceptive Neuronal Fc-gamma receptor I is involved in IgG immune complex induced pain in the rat. Brain Behav Immun 62:351-361; 2017.
- Liu F; Xu L; Chen N; Zhou M; Li C; Yang Q; Xie Y; Huang Y; Ma C*. Neuronal Fc-epsilon receptor I contr ibutes to antigen-evoked prur itus in a murine model of ocular allergy. Brain Behav Immun 61:165-175; 2017.
- Wang T; Ma C*. Peripheral Nociceptors as Immune Sensors in the Development of Pain and Itch. Adv Exp Med Biol. 904:77-85; 2016.
- Yuan T; Li J; Shen L; Zhang W; Wang T; Xu Y; Zhu J; Huang Y*; Ma C*. Assessment of Itch and Pain in Animal Models and Human Subjects. Adv Exp Med Biol. 904:1-22; 2016.
- Please check the lab website: http://anatomy.sbm.pumc.edu.cn/research.asp?typecode=1903
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