Changes to the knee joint during osteoarthritis.
Austria (AMSA) - University of Vienna, Vienna
Medical University of Vienna Center for Anatomy and Cell Biology Division of Anatomy
Prof. Dr. Michael Jantsch
Mag. DDr. Lena Hirtler
Required: English Accepted: Dutch
8 weeks
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Type of Research Project
- Basic science
What is the background of the project?
The knee joint is one of the major joints in the human body and one of the joints most frequently involved in osteoarthritis. Information on how the structures of this joint change and adapt during the development of osteoarthritis is scarce, especially looking to large scale evaluation of imaging data. In recent publications, already information was given on the multiple changes to the osseous and ligamentous structures of the joint during life, i.e. from childhood to old age. Based on the results of this study, risk factors may be defined, and the morphological understanding of osteoarthritis may be furthered.
What is the aim of the project?
To evaluate the morphological changes to the knee joint in different stages of osteoarthritis
What techniques and methods are used?
Evaluation of existing MRI-data: All images were acquired on a 3-Tesla Magnet Resonance Imaging (MRI) scanner (Philips Achieva® 3.0T; Philips Healthcare, Best, The Netherlands) with a standard knee coil (Philips SENSE® Knee, 8 elements; Philips Healthcare, Best, The Netherlands). All subjects were scanned using the same protocol: sagittal T1-weighted images; sagittal T2-weighted images with fat saturation; and sagittal, coronal, and axial proton density-weighted images with fat saturation. Measurements were obtained digitally with commercially available software (icoView®; ITH icoserve, Innsbruck, Austria). Morphometric analysis Analysis of the MR images was performed by two investigators with at least 3 years of experience in musculoskeletal MRI interpretation. Each investigator was blinded to the other’s findings to enable inter-rater evaluation. In case of differences regarding the presence of an Meniscofemoral Ligament (MFL), a joint decision was made. For continuous variables, the arithmetic mean of the investigators’ measurements was taken as the final value. The following variables were measured: presence or absence and length and running angle of the MFLs in the coronal plane; cross-sectional area (CSA) of the MFLs at the midpoint of length in the sagittal plane; CSA of the Posterior Cruciate Ligament (PCL) on the level of the joint line in the axial plane and detectability of the MFLs according to the MRI planes.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
- Knowledge of anatomy (i.e. knee joint and surrounding structures) - Literature review as introduction into the specific field - Definition of planned measurements of provided MRI and x-rays - Performing MRI and x-ray evaluation under supervision - Correct documentation of data - Planning of statistical evaluation - Correct statistical evaluation under supervision
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Introduction to MRI reading, guidelines to perform the respective measurements
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
- The student will prepare a scientific report
- The student will prepare an abstract
- The student’s name will be mentioned in a future publication
- The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- Profound anatomical knowledge - Basic knowledge of imaging evaluation - Basic knowledge of literature research - Basic knowledge of statistics
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Röhrich S; Kainberger F; Hirtler L. Eur Radiol. 2018 Jan 10. doi: 10.1007/s00330-017-5128-x. [Epub ahead of print]
- Hirtler L; Röhrich S; Kainberger F. AJR Am J Roentgenol. 2016 Aug 4:1-10. [Epub ahead of print]