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Antimicrobial multi-resistant bacterial pathogens. Detection and characterization of high risk clones associated with the dissemination and persistence.
Universidad Nacional de Tucuman
Faculty of Pharmacology and Biochemistry, Tucuman National University
Dr Marta Cecilia de Castillo
Dr. Maria Angela Jure
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The irrational use of antibiotics pressure on the microbial ecology selecting multiresistant strains which constitute an important reservoir and possible source of hyper-epidemic clone dissemination. Nowadays the surveillance systems work hardly on microorganisms with extreme-resistance. These microorganisms constitute a diagnostic and therapeutic challenge, related with the clinical evolution and the mortality rate in many patients. The search of strategies for the detection and molecular characterization of these bacteria is crucial for implementing the correct antibiotic therapy.
What is the aim of the project?
The aim of this study is “the detection and characterization of epidemic clones, genetic environment and plasmids associated with multi-resistant bacteria dissemination” to implement surveillance strategies in our region.
What techniques and methods are used?
Detection, monitoring, and characterization of drug-resistant bacteria: Antimicrobial resistance evaluation using the VITEK 2 system (BioMerieux). Resistance genes targeting: using multiplex polymerase chain reaction (PCR) technique Evaluation of the clonal strains relations using pulsed field gel electrophoresis (PFGE) Secuenciotype determination in multiresistant bacteria using Multilocus Sequence Typing (MLST) according to the MLST Database Mapping of gene resistance region in multiresistant bacteria using polymerase chain reactions (PCR)
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student´s plan will be organized into three focus areas: Surveillance, Prevention and Control and Research. The focus areas and goals are as follows: detection, monitoring, and characterization of drug-resistant infections in humans; evaluation of strategies to prevent the emergence, transmission, and persistence of drug-resistant microorganisms; evaluate strategies to improve appropriate antimicrobial use; facilitate basic research on antimicrobial resistance and the translation of basic research findings into practical applications for the prevention, diagnosis and treatment of resistant infections, conduct and support epidemiological studies to identify key drivers of the emergence and spread of AR in various populations.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Subjects passed: microbiology and molecular biology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields - Dental medicine students (IADS members)
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