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Microbiological and Immunobiological aspects in central nervous system infections
Bulgaria (AMSB) - Medical University of Plovdiv, Plovdiv
Department of Microbiology and Immunobiology , Medical University of Plovdiv
Prof. Dr. Mariana Murdjeva
Dr. Y. Kalchev , Dr. A. Petrova
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The anatomy of the brain and meninges determines the special character of central nervous system (CNS) infections. Fast and exact microbiological diagnosis of central nervous infections in crucial. As a result, immunoglobulins and immune-competent cells are scarce in the brain except at foci of inflammation. The space between cells in the brain parenchyma is too small to permit passage even of a virus. However, tetanus toxin and some viruses travel through the CNS by axoplasmic flow. The etiological diagnosis of meningitis and encephalitis is very important because the adequate antimicrobial therapy is based on its results. Some of the contemporary microbiological approaches to defer microorganisms in cerebrospinal fluid will be compared with their diagnostic characteristic.
What is the aim of the project?
To compare different microbiological methods for modern and fast diagnosis of meningitis .
What techniques and methods are used?
Instruction for working with the apparatus: 1.Multiplex PCR (polymerase - chain reaction ) 2.FISH (fluorescent - in - situ hybridization ) 3.Elisa (Enzyme-linked immunosorbent assay)for defection of pro - inflammatory cytokines The study includes the usage of the ELISA method, Multiplex PCR and FISH detection of antigens. To perform immunological tests using the described methods.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The study includes the usage of the ELISA method, Multiplex PCR and FISH detection of antigens. To perform immunological tests using the described methods .To observe different microbiological methods for defection of central nervous system infections.To learn how to interpret and analyze the result .To work (perform) different microbiological techniques in the aid of diagnosis To perform immunological tests using the described methods.To make statistical analysis of the date, to make literature review of the problem.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes - lectures and seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Skill with Microbiological cultures Subjects passed: Microbiology Previous experience with: microbiological work
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- Virus-induced autoimmunity: Epitope spreading to myelin autoepitopes in theiler's virus infection of the central nervous system Stephen D.MillerYaelKatz-LevyKatherineL.NevilleCarolL.Vanderlugthttps://doi.org/10.1016/S0065-3527(01)56008-X
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