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Characterization of longevity genes by genome and target sequencing
Bulgaria (AMSB) - Medical University of Sofia, Sofia
Department of Medical genetics, Medical faculty, Medical university of Sofia
Corr.memb. Draga Toncheva,MD,DSc
Corr.memb. Draga Toncheva,MD,DSc
Type of Research Project
- Basic science
What is the background of the project?
Ageing is a genetically programmed process that arises as a result of the declining ability of the human organism to maintain its homeostatic balance and to regenerate its damaged cells and tissues.The exact biological basis of the complex process of organismal ageing is still not clearly understood. The centenarian genome can be regarded as the ‘gold standard’ for the discovery of genetic determinants of healthy longevity and protection from diseases. Whole-genome data from centenarians will allow to search for the factors promoting healthy ageing across the genome, as well as to potentially unfold some of the secrets of human physiology.
What is the aim of the project?
The overall goal of this project is to reveal genetic loci associated with longevity in Bulgarian centenarians and elucidate some of the biological mechanisms and signalling pathways contributing to an increased healthy lifespan based on the findings.
What techniques and methods are used?
Whole-genome sequencing (WGS) of centenarian genomes will be performed, followed by targeted sequencing of nominated candidate genes in another cohort of 50 centenarians, as well as in 100 age- and location-matched controls aged 20-30 years.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be expected to take active part in the research project. This will include review of the literature on his/her own, participation in scientific discussions and seminars, lab work and analysis of the results under supervision. The student will take part in preparation of samples for targeted sequencing, software analysis of genomic data and database research for genomic variants. The student will participate in database research for genomic variants and statistical analysis of obtained data. Written report and oral presentation on the objectives, methodology and results of the student’s work are recommended.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary seminar on: Next-generation sequencing (NGS) methodology Software data analysis of genomic data
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Being familiar with general rules for good laboratory practice Subjects passed: Medical genetics
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- Passarino G; De Rango F; Montesanto A. Human longevity: Genetics or Lifestyle? It takes two to tango. Immunity & Ageing : I & A. 2016;13:12. doi:10.1186/s12979-016-0066-z
- 1. https://www.illumina.com/content/dam/illumina-marketing/documents/products/illumina_sequencing_introduction.pdf
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