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Ethnopharmacological investigations of the cardiorenal properties of native species from the mesoregion of pantanal, mato grosso do sul state, brazil
Federal University of Grande Dourados – UFGD
LABORATORY OF ELETROPHYSIOLOGY AND CARDIOVASCULAR PHARMACOLOGY, FACULTY OF HEALTH SCIENCES (FCS), UNIVERSIDADE FEDERAL DA GRANDE DOURADOS (UFGD)
Profa. Dra. SILVIA APARECIDA OESTERREICH
Prof. Dr. ARQUIMEDES GASPAROTTO JUNIOR
English, Spanish, Portuguese
Type of Research Project
- Basic science
What is the background of the project?
The use of popular knowledge in the identification of medicinal native species that can reduce blood pressure levels can strengthen the belief that hypertension control is possible and might provide additional benefit. In Brazil, traditional knowledge about medicinal plants is the basis of popular medicine. The knowledge is transmitted orally over generations and some of this information are getting lost, which justifies the need for this knowledge to be retrieved and transcribed. Brazilian biodiversity is an inexhaustible source for research with unique biological diversity. Pantanal is the one of the most immensurable, primitive and biologically rich environments of the world. In Brazil, 64.4 percent of Pantanal is located in state of Mato Grosso do Sul (MS). Different indigenous and riverine populations are among the different populations that live in this ecosystem, which preserve very important knowledge about the benefits of several medicinal species native of the region.
What is the aim of the project?
The present project aims to identify the medicinal species commonly prescribed by healers from de mesoregion of Pantanal Sul-Matogrossense.
What techniques and methods are used?
The project will work with hypothesis, study area, interview with healers about medicinal plants used in the region, ethnobotanical survey, species collection and herborization, anatomical analysis, histochemical study, Field Emission Scanning Electron Microscopy (FESEM) and Energy- Dispersive X-ray Spectroscopy (EDS), Preparation of the purified aqueous extract, phytochemical analysis (liquid chromatography-mass spectrometry; LC-MS), toxicological study, experimental group, renal functions, blood pressure and heart rate evaluation, mesenteric vascular reactivity, serum biochemical parameters, determination of tecidual reduced glutathione (GSH) levels, GST, SOD, and CAT activity, investigation of the molecular mechanisms involved in the vasodilatory response od herbal extracts (ESFs), data analysis and quantitative factors, statistical analysis.
What is the role of the student?
- The student will mainly observe
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
It is expected that the student will be able to accomplish all programmed activities, fulfill the tasks given by the tutors and consolidate their own knowledge in the subject. It is expected that the student can join the group of laboratory members and that he/she can contribute with the project with his/her own background. As mentioned on the techniques section, the students will be able to interview native people, as well to use the practical skills for preparing the extracts and analyzing the products, confirming or not the efficience of the native plants species on healing.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1 lecture on the first day explaining the importance of the subject and native plants species.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have already knowledge of laboratory biosafety, brings his/her own lab coat and logbook.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Ethnopharmacological approaches to kidney disease- prospecting an indigenous species from Brazilian Pantanal. J Ethnopharmacol. 2018 Jan 30;211:47-57.
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