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Preclinical evaluation of medicinal plants for the treatment of chronic inflammatory diseases of the skin
Brazil (IFMSA-Brazil) - Universidade Federal do Parana (UFPR), Curitiba
Daniela Cabrini, PhD
Michel Otuki, PhD., Daniela Cabrini PhD
Type of Research Project
- Basic science
What is the background of the project?
The project developed by the group produced more than 20 scientific articles and has helped to strengthen the scientific evidence for the use of medicinal plants for the therapeutic purpose. In addition, the project has trained dozens of undergraduate, master and doctoral students. Many plants are found to possess reliable pharmacological properties and have started to attract the attention of researchers. Recently, there has been a remarkable progress in the field of antiviral herbal therapy owing to increasing concerns about the development of drug resistance and limited advances in the field of antiviral drug discovery. In almost all countries, medicinal plants have been used widely throughout history for the treatment of diseases and infections as traditional healing remedies due to their broad therapeutic spectrum and minimal or no side effects. In this way, investing in research on medicinal plants represents a considerable scientific advance in medicine.
What is the aim of the project?
The project aims to validate plants used by the population as well as perform the prospection of new therapies for the treatment of inflammatory skin disease of plant origin.
What techniques and methods are used?
Animal models of psoriasis and dermatitis as well as cell culture methods of keratinocytes and lymphocytes were used as methods of this research for the analysis of the potentiality profile of the use of medicinal plants in these pathologies. Cell culture and should fulfill only tasks requested by the supervisor as the search for scientific evidence.This project aims to analyze the interference of herbal properties in the present research and will be able to understand the main mechanisms of control and interference between the pathologies involved in this research and how the use of medicinal plants may be beneficial for future research in this field not only as a space in alternative medicine.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be supervised in tasks related to preclinical methods such as cell culture and should fulfill only tasks requested by the supervisor as the search for scientific evidence. The student will be assisted by his supervisor to analyze the interference of herbal properties in the present research and will be able to understand the main mechanisms of control and interference between the pathologies involved in this research and how the use of medicinal plants may be beneficial for future research in this field not only as a space in alternative medicine but also within the traditional Western medicine scene. In this way, the exchange student may have a great opportunity for academic growth by carrying out this research.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes. Some articles wil be sent to the student before the exchange starts.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Hability to work as a team
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- • Prudente AS et al. Pre-clinical efficacy assessment of Malva sylvestris on chronic skin inflammation. Biomed Pharmacology 2017.
- • Farahnik B. Topical Botanical Agents for the treatment of Psoriasis AmJ Clin Dermatol 2017
- • Di Meglio. Psoriasis. Cold Spring Harb Perspect. Med 2014.
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