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Effects of Dipotassium Glycyrrhizinate (DPG) on skin and muscle regeneration
(University Sao Francisco) Universidade Sao Francisco (USF)
Laboratory of Multidisciplinary Research, São Francisco University Medical School, Bragança Paulista, SP, Brazil
Type of Research Project
- Basic science
What is the background of the project?
The Dipotassium Glycyrrhizinate, a derivate of Glycyrrhizic Acid, is being studied because of its effects as an anti-inflammatory without side effects, which acts over by nuclear factor kappa-light-chain-enhancer of activated β cells (NK-Kβ) complex inducing all regeneration. The DPG can effectively remove superoxide and hydroxyl radicals. It also has good anti-inflammatory effect, inhibits lipid peroxide functions, and is easily absorbed into the skin. The antioxidant action is important because antioxidants are compounds that act by inhibiting and / or decreasing effects triggered by free radicals and oxidizing compounds.
What is the aim of the project?
Study the effects of DPG on skin and muscle regeneration in a way to understand its mechanism of action.
What techniques and methods are used?
To achieve the goal of the project, the student will induce an injury in the animal creating skin wounds by muscular poisonig. The student will use the histopathological techniques as Hematoxylin-Eosin, Immunofluorescence, Immunohistochemistry, Western Blot and Polymerase Chain Reaction.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will prepare histological samples and analyze them by his / her own, using the histopathological techniques Hematoxylin-Eosin, Immunofluorescence, Immunohistochemistry, Western Blot and Polymerase Chain Reaction. Furthermore, he / she will help holding and operating the animals to induce the skin or muscle injury. From this, the student will analyze the results for possible future discussion with his / her trainee supervisor about the expected results of the research project and compare if the results found are the same or different from the results expected to confirm or not the initial hypothesis. In addition, the student will compare the results obtained with the use of the three different techniques performed to carry out the research, namely hematoxicillin-eosin, immunofluorescence and immunohistochemistry, western blot and polymerase chain reaction.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, some articles will be send to the student before the exchange starts.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
He/she must have biology and histology background and not to be afraid of animals such as rats and mice. Subjects passed: all biology and histology until the exchange starts .
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Students in biomedical fields
- Biological characterization of Bothrops marajoensis snake venom. Cavalcante WL; Hernandez-Oliveira S; Galbiatti C; Randazzo-Moura P; Rocha T; Ponce-Soto L; Marangoni .
- • S; Pai-Silva MD; Gallacci M; da Cruz-Höfling MA; Rodrigues-Simioni L. https://www.ncbi.nlm.nih.gov/pubmed/22091348
- • Effects of tretinoin on wound healing in aged skin. de Campos Peseto D; Carmona EV; Silva KC; Guedes FR; Hummel Filho F; Martinez NP; Pereira JA; Rocha T; Priolli DG. https://www.ncbi.nlm.nih.gov/pubmed/26834030
- • The greater black krait (Bungarus niger); a newly recognized cause of neuro-myotoxic snake bite envenoming in Bangladesh. Faiz A; Ghose A; Ahsan F; Rahman R; Amin R; Hassan MU; Chowdhury AW; Kuch U; Rocha T; Harris JB; Theakston RD; Warrell DA. https://academic.oup.com/brain/article/133/11/3181/316628/The-greater-black-krait-Bungarus-niger-a-newly
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