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Assessment of molecular response to Imatinib therapy in Chronic Myeloid Leukemia patients
Iraq (IFMSA-Iraq) - Al-Mustansiriya University/ College of Medicine, Baghdad
Dr. Basim Shihab Ahmed
Dr. Alauldeen Mudhafar Zubair
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The pathognomonic genetic alteration in CML (Chronic Myeloid Leukemia) is the formation of BCR-ABL fusion gene which produces tyrosine kinase that drives leukemic transformation. Targeted tyrosine kinase inhibitor is the treatment of choice. Hematological response is assessed by complete blood count and by hematology autoanalyzer. Molecular response is assessed by real-time PCR (polymerase chain reaction) are necessary techniques for monitoring therapy and quantitatively assessing minimal residual disease. This assessment is essential for treatment decision e.g: continuation of the same drug or switching to a new generation.
What is the aim of the project?
Assessing molecular response to Imatinib by measuring BCR-ABL Transcripts using Real-time PCR
What techniques and methods are used?
1- Complete blood count by hematology autoanalyser. 2- Real-time polymerase chain reaction for detection of BCR-ABL Transcripts (breakpoint cluster region protein- Abelson murine leukemia viral oncogene homolog)Transcripts.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1-Receive patients 2-Take medical history and perform physical examination. 3- Review case sheets, treatment history and review diagnosis. 4- Explain the benefit of RT-PCR test to them. Help perform the test in the lab and learn to interpret the result. The student will work with Iraqi medical students, which will help overcome the language barrier, and the work will mostly be in the laboratory
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1- Didactic lectures on CML,Treatment options and assessment of response. 2- Introduction to Real-time PCR technique and its application in leukemia diagnosis and response followup.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
1- Taking medical history & physical examination 2-Basic lab work (sample collection, handling, and test. Collection and interpretation of data. Maintenance of accurate records and reporting of data. Instrument operation)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Foroni L1; Wilson G; Gerrard G; Mason J; Grimwade D; White HE; et al. Guidelines for the measurement of BCR-ABL transcripts in Chronic Myeloid Leukemia; British Journal of Hematology 2011:153 (2): 179-190
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