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Resistance of bacterial pathogens to antibiotics and antibiotic therapy of serious infections
Czech Republic (IFMSA CZ) - Palacky University, Olomouc
Department of Microbiology Faculty of Medicine and Dentistry, Palacký University Olomouc
Prof. MUDr. Milan Kolář, Ph.D.
Prof. MUDr. Milan Kolář, Ph.D., Mgr. Patrik Mlynárčik, Ph.D.
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Increasing bacterial resistance to antibiotics is one of the most serious problems in current medicine. It is known from earlier studies that bacterial resistance frequently results in inadequate antibiotic therapy, thus increasing morbidity and mortality rates and prolonging treatment and increasing treatment costs. An important factor contributing to the growing prevalence of multiresistant bacteria is application of antibiotics. For example, important mechanism of resistance is production of broad-spectrum beta-lactamases, increasingly detected not only in bacterial pathogens but also in bacteria contained in the normal microflora of the human body. The objectives of the projects will be determination and analysis of the prevalence of multiresistant Extended Spectrum Beta-Lactamases and AmpC-positive Enterobacteriaceae, methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococciin biological specimens of patients hospitalized at University Hospital Olomouc.
What is the aim of the project?
This project will aim at analyzing the level of resistance of most important bacterial pathogens to selected antibiotics in the University Hospital Olomouc, Czech Republic, and assessing the treatment options of serious bacterial infections.
What techniques and methods are used?
Susceptibility to antibiotics will be determined by the standard microdilution method according to the The European Committee on Antimicrobial Susceptibility Testing criteria. Beta-lactamase phenotypes were determined by relevant phenotype tests and, if needed, the results were confirmed by detection of genes encoding the enzymes.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The aims of the clinical microbiology laboratory. Principal microbiological procedures. Collection, handling and transport of clinical specimen. Microscopic techniques for diagnosis of infection. Identification of microorganisms. Cultivation of bacteria. Determination of bacterial resistance to antibiotics. Detection of resistance phenotype: - extended-spectrum beta-lactamases - AmpC - Klebsiella pneumoniae carbapenemase - metallo-beta-lactamase - methicillin-resistant Staphylococcus aureus - vancomycin - resistant enterococci
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Articles are stated below.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Exam from Medical Microbiology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Herkel T; Uvizl R; Adamus M; et al. Epidemiology of hospital-acquired pneumonia: results of a Central European multicenter; prospective; observational study compared with data from the European region. Biomedical Papers. 2016; 16:448-455.
- Pudová V; Htoutou Sedláková M; Kolář M;et al. Clonality of bacterial pathogens causing hospital-acquired pneumonia. Current Microbiology. 2016; 73:312-316.
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