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A study on the mechanism of enhanced glutathione export by intracellular cysteine
Korea (KMSA) - Ulsan university, Seoul
Department of Pharmacology
Type of Research Project
- Basic science
What is the background of the project?
Glutathione is a tripeptide functioning as the primary antioxidant against hydrogen peroxide and numerous toxic electrophiles. Its intracellular concentration is tightly controlled by regulated synthesis, recycling and export through MRP1, a transporter of glutathione conjugate and glutathione itself. We have recently discovered that cysteine, the essential building-block of glutathione, stimulate the export of glutathione through MRP1 (multidrug resistance protein 1). We speculated that this is another regulatory mechanism involved in glutathione homeostasis. Now we are trying to elucidate the detailed mechanism of this phenomenon.
What is the aim of the project?
To develop a new measure for the manipulation of glutathione export
What techniques and methods are used?
Basic experimental methods of the project include cell culture, biochemical and enzymatic analysis of cysteine/glutathione, pharmacological intervention of MRP1, cell death assay, etc. Since the on-going research in our laboratory is mainly based on experiments using cultured cells, statistical analysis of the data is of secondary importance. No further statistical methods other than ANOVA and t-test will be required.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
Firstly, I expect that the students study the background of the project under my guidance and supervision to understand the design and purpose of the project. After that, the students will be encouraged to perform some easily-acquirable experimental techniches such as cell culture and biochemical analysis under supervision of myself and my research assistant, who is also a medical college graduate. What I mostly expect is the active participation of the students in the discussion of the experimental results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- YJ Seo; JW Lee; EH Lee; HK Lee; HW Kim; Y-H Kim. Role of glutathione in the adaptive tolerance to H2O2. Free Radical Biology and Medicine; 37(8):1272-1281; 2004
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