Effect of concurrent aromatase inhibitor with adjuvant radiotherapy on hormone receptor-positive postmenopausal breast cancer patients
Egypt (IFMSA-Egypt) - Assiut University, Assiut
South Egypt Cancer Institute
Prof. Dr. Moustafa Elsharkawy
Dr. Nora Essam Mohamed Elwy
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes No No No No Yes Yes Yes No No No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Breast cancer is the most common cancer among egyptian women, accounting for 35% of all cases treated at the institute. Radiobiological preclinical data indicates that radiotherapy with aromatase inhibitors results in a steeper decline in cell survival due to both: higher initial slope of the dose-response curve and to a major decrease of the quadratic parameter. Aromatase inhibitor will be added at least 6 days before radiotherapy lead to a greater decrease of the surviving fractions as compared with those obtained when aromatase inhibitor was added 3 days before radiotherapy.these radiobiological outcomes may form the basis for concurrent use of aromatase inhibitor and radiation as postsurgical adjuvant therapy for breast cancer due to their additive effects which enhance cytotoxicity and improve tumor response.
What is the aim of the project?
Primary objectives is to determine: If starting aromatase inhibitor with adjuvant radiotherapy (in post-menopausal hormonal receptor positive breast cancer patients ) will decrease the local recurrence and improve the local control by acting as an enhancer of the radiation. Secondary objectives are to determine the effect of this combination on : Rates of distant failure Normal tissue complications
What techniques and methods are used?
- Inclusion and exclusion of patients - Pre-treatment evalution - Systemic therapy - Hormonal therapy - Radiotherapy - Follow up - Statistical methods
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will actively participate in patients grouping, data analysis and results comprehension are expected to be done under supervision of the professor first, then done by student's own, and the professor will review and discuss the results with them at the end.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Lectures concerning the topic and presentation of the clinical skills used.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It's preferred if the student has studied oncology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Desantis C; Siegel R; Bandi P; Jemal A. Breast cancer statistics; 2011. CA cancer J CLIN 2011;61:409-18. Doi:10.3322/caac.20134. Available.
- Ferlay J; Shin H-R; Bray F; Forman D; Mathers C; Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J cancer 2010;127:2893-917.doi : 10.1002/ijc.25516.
- Darby S; McGale P; Correa C; Taylor C; Arriagada R; Clarke M; eh al. Effect of radiotherapy after breast-conserving surgery on 10;801 women in 17 randomised trials. Lancet (London;England)2011;378:1707-16. Doi:10.1016/S0140-6736(11) 61629-2.