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Patophisiology of multiple myeloma: role of the bone marrow microenvironment
Universita degli Studi di Parma
Department of Medicine and Surgery _ Via Gramsci 14, 43126 Parma, Italy
Prof. Antonio Mutti
Prof. Nicola Giuliani - email@example.com
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Multiple Myeloma (MM) is an incurable hematological malignancy characterized by the tight _ relationship with the bone marrow (BM) microenvironment that protect MM cells from drug-induced apoptosis. In the last years our research group have studied the mechanisms involved in the pro-angiogenic switch, immunosuppression and bone distruction induced by MM cells, indentifying several potential new therapeutic targets also clarifying the mechanisms of anti-MM drugs . _
What is the aim of the project?
To investigate the role of the BM microenvironment cells (endothelial cells, osteoblasts, osteoclasts, immune cells) in the resistance to the new anti-MM drugs (proteasome inhibitors, immunomodulatory agents, monoclonal antibodies)
What techniques and methods are used?
1) Cell culture of microenvironment cells exposed to different anti-MM drugs 2) purification of microenvironment cells from MM patients resistant or responding to therapy 3) transcriptional, immunophenotyping, proteomic analysis of microenvironment cells from MM patients.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
-Clinical examination of the patients; - Management of peripheral blood and BM samples; - Mononuclear cell purification and isolation of the different microenvironment cell fraction by immunomagnetic methods; - Bio-banking and storing of cell samples; - Management of data base and statistical analysis. Yes, skype conference is required before the acceptance of the student.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminar readings, lectures, seminars, clinical and laboratory meetings.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Previous laboratory expertise, knowledge of hematological diseases Subjects passed: hematology or equivalent Previous experience with: cell culture, blood sample manipulation
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
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