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Antiviral Targeting of Emerging Viruses Using Viral Pseudoparticle System & Viral Modeling for the Development of Measles-Based Oncolytic Virotherapyt"
Taiwan (FMS-Taiwan) - Taipei Medical University, Taipei
LTL Lab, Dept. Microbiology & Immunology, Taipei Medical University, United Medical Building 10F, No. 250, Wu-Hsing Street, Taipei 11031 Taiwan
English; Mandarin; French
Type of Research Project
- Basic science
What is the background of the project?
1. Emerging and re-emerging viral infections represent a global threat to public health. Development of antivirals is especially important for viral infections that are without effective or FDA-approved vaccines or antiviral treatments. Viral pseudoparticles are engineered viral particles that mimic a single round of replicative life cycle of viruses, and are useful for the identification of antivirals that target early phases of the viral life cycle. 2. Oncolytic virotherapy using viruses that preferentially target and kill cancer cells represents a novel therapy for the management of cancers. Significant challenges that remain include enhancing cancer cell-targeting specific and increasing tumor-killing efficiency. We employ measles-based viral vectors and engineer them to be highly specific to attacking cancer cells.
What is the aim of the project?
1. To develop viral pseudoparticles of emerging viruses that mimic their natural life cycle as a drug-screening platform for the identification of novel antivirals. 2. To develop measles virus-based oncolytic vectors with high specificity to cancer cells and increased tumor killing efficiency.
What techniques and methods are used?
Techniques include: cell/virus culture, drug treatment analyses, immunofluorescence microscopy, toxicity analysis, and basic molecular biology assays. Step1: Basic virology & molecular cell biology training. Step 2: Antiviral testing using viral pseudotypes and oncolytic vector development Step 3: Data analysis & laboratory presentation training
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The students are expected to participate the laboratory experiments and undergo training in laboratory safety practice. Students are also expected to attend the laboratory meetings and be able to give a brief presentation upon the completion of the exchange program. The students will learn molecular and virology techniques including: cloning, DNA/RNA preparation/extraction/purification, Western blot, immunofluorescence, flow cytometry, cell culture/assays, virus culture/assays, drug analysis. Students will be led by senior members of the laboratory and are expected to have hands-on participation.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Readings will be assigned throughout the study; we also hold weekly laboratory meetings to assess the work in progress; seminars are offered to all students joining the laboratory.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It is preferred that the students have basic knowledge in virology and molecular/cellular biology, as well as some basic research and laboratory skills. The students are however welcome to learn during their exchange program in the laboratory.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- - Follenzi et al. HIV-based vectors. Preparation and use. Methods Mol Med. 2002;69:259-74.
- - Bartosch et al. Studying HCV cell entry with HCV pseudoparticles (HCVpp). Methods Mol Biol. 2009;510:279-93.
- - Msaouel et al. Oncolytic measles virus strains as novel anticancer agents. Expert opinion on biological therapy 2013; 13(4):483-502.
- - Mahoney et al. Potentiating oncolytic viruses by targeted drug intervention. Curr Opin Mol Ther 2010; 12(4):394-402.
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