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Liquid biopsy methods to investigate genetic markers in lung cancer
Università degli studi di Padova
Immunology and Molecular Oncology Unit – Istituto Oncologico Veneto – IRCCS, via Gattamelata, 64, 35128 Padova, Italy
Prof. Alberto Amadori
Dr. Stefano Indraccolo - firstname.lastname@example.org
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The Project seeks to investigate mutations in established driver or actionable genes in the peripheral blood of lung cancer patients. The search of mutations in certain genes, such as EGFR, is important for therapeutic purposes in NSCLC patients (non small cells lung cancer patients), as such mutations are required for prescription of EGFR tyrosine kinase inhibitors (TKI). Detection of mutations in other common driver genes (such as KRAS or TP53) in circulating tumor DNA (ctDNA) could be useful to monitor therapeutic response to a variety of drugs. http://ioveneto.it/ricerca/scientific-report/ricercatori/dr-stefano-indraccolo-md/
What is the aim of the project?
The aim of the Project is to detect mutations in certain genes associated with lung cancer pathogenesis in the peripheral blood of patients and to monitor their quantitative variations during medical treatment.
What techniques and methods are used?
The Project involves the use of techniques to purify Circulating tumor DeoxyriboNucleic Acid (ctDNA) and to analyze it, including digital droplet Polymerase Chain Reaction (ddPCR) and next generation sequencing (NGS) techniques.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
As the Project involves analysis of precious clinical samples by expensive techniques it is not possible to let the student perform himself/herself these experiments. The student will be welcome to participate in data analysis and filling the molecular diagnostic report. The student will be always under the guide and the supervision of the tutor or a collaborator of the tutor.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Since our Institute participates to a Ph.D program in Oncology, with regular seminars in English, there might be a chance to attend 1-2 seminars during the 1 month staying.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good knowledge of written and spoken English. A certain knowledge of molecular biology methods is encouraged.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Morphological and genetic heterogeneity in multifocal lung adenocarcinoma: The case of a never-smoker woman. Bonanno L; Calabrese F; Nardo G; Calistri D; Tebaldi M; Tedaldi G; Polo V; Vuljan S; Favaretto A; Conte P; Amadori A; Rea F; Indraccolo S. Lung Cancer. 2016 Jun;96:52-5. doi: 10.1016/j.lungcan.2016.03.009.
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