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Studies on the control of cell death by inhibition of lipid peroxidation
Università degli studi di Padova
Department of Molecular Medicine (DMM) Viale G. Colombo 3 - 35131 Padova
Prof. Mariacristina Parolin
Fulvio Ursini -
Type of Research Project
- Basic science
What is the background of the project?
The study expands information on GPX4, the peroxidase containing selenium, discovered by this group, and its control of a specific form of cell death named “ferroptosis”. The study encompasses enzymology, cell biology, proteomic and lipidomic studies, it uses cell cultures and recombinant proteins.
What is the aim of the project?
The project aims to show that cells are more or less prone to cell death when controlled concentration of glutation and controlled GPX4 activity are imposed.
What techniques and methods are used?
Enzymology and lipidomics techniques and cellular biology techniques (for example in vitro cultures and recombinant protein production)
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will take part in the design of the experiments, the collection and discussion of the data obtained. The role will be predominantly observational, however, he or she may do various laboratory activities under supervision of the tutor. For example the student will help tutor in the preparation of cell cultures, the analysis of cell death and the analysis of enzymatic activities.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will participate to lab meetings on ongoing research.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
SUBJECTS PASSED: cellular biology, biochemistry and physiology SPECIAL REMARK: The student must have white coat
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Orian L; Mauri P; Roveri A; Toppo S; Benazzi L; Bosello-Travain V; De Palma A; Maiorino M; Miotto G; Zaccarin M; Polimeno A; Flohé L; Ursini F. Selenocysteine oxidation in glutathione peroxidase catalysis: an MS-supported quantum mechanics study. Free Radic Biol Med. 2015 Oct;87 1-14. doi:10.1016/j.freeradbiomed.2015.06.011. PMID: 26163004
- Cozza G; Rossetto M; Bosello-Travain V; Maiorino M; Roveri A; Toppo S; Zaccarin M; Zennaro L; Ursini F. Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center. Free Radic Biol Med. 2017 Nov;112 1-11. doi:10.1016/j.freeradbiomed.2017.07.010. PMID: 28709976
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