Projects
Name
Genetics of familial thyroid cancer
University
Universita degli Studi di Bologna
Domain
Genetics
Departement
Dept of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, Bld 11-II floor, Bologna, Italy
Head
Marco Zoli
Tutor
Elena Bonora, elena.bonora6@unibo.it
Languages
English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes No No No No No
Type of Research Project
- Basic science
What is the background of the project?
Familial aggregation is a significant risk factor for the development of thyroid cancer derived from follicular epithelial cells (Non-Medullary Thyroid Carcinoma, NMTC). Whole exome sequencing analysis led the PI's group to identify a novel mutation in MYO1F in the 19p13.2 locus (TCO, Thyroid Carcinoma with cell Oxyphilia). Understanding the functional role of this mutation on thyroid function and tumour-related properties will represent a main goal of the project.
What is the aim of the project?
The overall goal of the project is to identify genetic variants conferring famNMTC predisposition, and to assess the impact of the MYO1F mutation on thyroid function and tumour-related behavior. Identifying the genetic factors conferring thyroid cancer predisposition will make it possible to predict who is at increased risk of developing the disease, allowing for early detection and therapy, and optimized patient management.
What techniques and methods are used?
This reseach project includes the use of next generation sequencing technologies, Polymerase Chain Reaction, cell cultures, western blotting, immunofluorescence. The results of each exam will be studied over and data collected.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will observe the activities of the laboratory and will not take part in practical activities but only be able to watch them. The student will follow one specific project on which the team is working, not multiple projects. The activities of the laboratory can be divided into two groups: use of diagnostic tools to collect data, analysis of the collected data.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No, just a general introduction SPECIAL REMARK I would like to have a conference call to discuss the interests of the student and their knowledge of the field
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
none
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Students in biomedical fields
Articles
- Canzian et al; AJHG 1998; Bonora et al;Cancer Research 2006; Bonora et al; Journal of Oncology 2010; Bonora et al; Int J Cancer 2014