[Sousse]The study of long term follow-up of virologic response of peginterferon alfa 2 a in Tunisian patients with hepatitis B.
Tunisia (ASSOCIA-MED) - University of Sousse/ Faculty of Medecine of Sousse, Sousse
Infectious Diseases
Department of Infectious Diseases - Farhat Hached University Hospital IBN JAZZAR Avenue 4000 Sousse, Tunisia
Pr. Amel Omezzine Letaief
English, French
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No yes yes yes No No yes yes yes yes yes No
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
Tunisia has a moderate endemicity in hepatitis B. Chronic hepatitis B is associated with high morbidity and mortality. Several randomized clinical trials have reported that therapy with recombinant interferon alfa increases the rate of elimination of hepatitis B e antigen (HBeAg). The most predominant genotype is the genotype D known to be a poor responder to interferon. In Tunisia, the health insurance supports 48 weeks of pegylated interferon for chronic hepatitis B patients. Some studies have evaluated the long- term response of pegylated interferon in patients with chronic hepatitis B in other countries.
What is the aim of the project?
This project examines the long-term efficiency of peginterferon alfa-2a (PEG-INF) beyond 6 months and predictors of sustained virological response in patients with chronic hepatitis B (CHB).
What techniques and methods are used?
- Data capture and analysis: by working essentially on spss, which is a software used for this matter. - Elaborate an adequate database  - Clinical examination of the patient - Questioning of the patient (eating habits and physical activity practice)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Clinical examination of the patient : The aim of the initial physical examination is to check for signs of chronic liver disease, which include the following: skin, heent, abdomen, extremities, neurologic, extrahepatic manifestations. - The project is actually in the stage of data analysis, the student is supposed to participate in this phase. - The collection of data according to a specific aim that will be fixed with his tutor in the work-folder. - The student will use Statistics included in the base software : SPSS :  Descriptive statistics: Cross tabulation, Fréquencies, Descriptives, Explore, Descriptive Ratio Statistics  Bivariate statistics: Means, t- test, ANOVA, Correlation (bivariate, partial, distances), Nonparametric tests  Prediction for numerical outcomes: Linear regression  Prediction for identifying groups: Factor analysis, cluster analysis (two-step, K-means, hierarchical), Discriminant
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Some readings will be given by the tutor.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
- The student will prepare a scientific report
- The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- The social and psychological skills of clinical questioning - The knowledge about the methods of data analysis.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
- Maurizia Rossana Brunetto; Francesco Moriconi; Ferruccio Bonino; George K. K. Lau; Patrizia Farci; Cihan Yurdaydin; Teerha Piratvisuth; Kangxian Luo; Yuming Wang; Stephanos Hadziyannis; Eva Wolf; Philip McCloud; Richard Batrla; Patrick Marcellin First published: 2 December 2008 DOI: 10.1002/hep.22760  Cited by (CrossRef): 268 articles