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COMPARISON BETWEEN THE IMPACT OF VARICOCELECTOMY, ORAL L-CARNITINE AND BOTH ON SPERM CHROMATIN CONDENSATION IN INFERTILE MEN WITH VARICOCELE
Egypt (IFMSA-Egypt) - Suez Canal University, Suez Canal
Dermatology and Venereology department
Prof. Mona Atwa
Ass. Prof. Rashad Mahmoud Mostafa / Dr. Yasser Salem Nasr
Required: English Accepted: Arabic
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Varicocele is recognized as the most common cause as well as the most common surgically correctable cause of male infertility. The prevalence of varicocele has been reported to be as high as 10-15% in the general population, 30-35% in men with primary infertility and 69-81% in men with secondary infertility. Varicocele associated infertility can be related to many factors that one of them could be the increase in the degree of Deoxyribonucleic acid (DNA) fragmentation and chromatin damage. A significant increase in abnormal sperm chromatin condensation in infertile men with varicocele could occur as a consequence of protamine deficiency indicating that a major spermatogenic insult affecting fertility in varicocele patients takes place at the spermatid level.
What is the aim of the project?
To compare the effect of varicocelectomy, L-Carnitine and varicocelectomy plus L-Carnitine on sperm chromatin condensation in infertile men with varicocele.
What techniques and methods are used?
Participants are alternatively allocated into one of three experimental groups that are randomized.All patients are subjected to; clinical evaluation, semen analysis and biochemical invetigations.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Collecting medical history (done under supervision). Performing general and local examination (done under supervision). Collecting blood samples for lab measurements (done under supervision). Collecting the data about semen analysis and then contributing in giving results (done under supervision). Study and explain the basics of varicocele and its relation to male infertility (done alone).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Theoretical teaching about history, examination, clinical skills, interpreting lap results in form of lectures and clinical talks. 2-3 lectures per week conducted by tutors mentioned above.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Know how to take medical history and perform a general examination. Interpretation of microscopic and biochemical examination of semen and Doppler ultrasound.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Thonneau P; Marchand S; Tallec A; et al. Incidence and main causes of infertility in a resident population (1;850;000) of three French regions (1988-1989). Hum Reprod 1991;6:811-6.
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