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HYPOGONADISM AMONG MALE PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
Egypt (IFMSA-Egypt) - Suez Canal University, Suez Canal
Dermatology and Venereology department
Prof. Mona Atwa
Ass. Prof. Rashad Mahmoud Mostafa / Dr. Yasser Salem Nasr
Required: English Accepted: Arabic
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Obstructive sleep apnea (OSA) affects approximately 4% of adult males. It is characterized by intermittent cessation of airflow at the nose and mouth during sleep. Apneic events are typically 20 to 30 s in duration and may be as long as 2 to 3 min. Apnea-related hypoxia leads to arousal and termination of the obstructive events. In addition to daytime sleepiness, OSA causes a number of deleterious physiologic consequences. Cardiovascular problems include recurrent bradycardia and tachyarrhythmias, systemic hypertension, and increased risk of congestive heart failure. Metabolic consequences include hypoxia, polycythemia, and insulin resistance. Several studies have reported decreased testosterone and reduced libido or sexual dysfunction in men with OSA. However, the physiologic basis for testosterone deficiency is unknown. Specifically, it is not clear whether the reduction in testosterone results from gonadotropin suppression versus a primary defect in testicular Leydig cells.
What is the aim of the project?
This study aims to evaluate if a relation exists between hypogonadism and obstructive sleep apnea (OSA).
What techniques and methods are used?
Measurement of the nocturnal serum luteinizing hormone (LH) and testosterone levels and sleep recordings. This study is carried out in the andrology outpatient clinic at Suez Canal University and subdivided into two groups, infertile men with hypogonadism and infertile men without hypogonadism.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Collecting medical history (done under supervision). Performing general and local examination (done under supervision). Collecting blood samples for lab measurements (done under supervision). Collecting the data about T and LH and then contributing in giving results (done under supervision). Study and explain the basics of male infertility and its causes (done alone).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Theoretical teaching about history, examination, clinical skills, interpreting lap results in form of lectures and clinical talks. 2-3 lectures per week conducted by tutors mentioned above.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Know how to take medical history and perform a general examination. Interpretation of Testosterone and luteinizing hormone results.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Luboshitzky R; Aviv A; Hefetz A; Herer P; Shen-Orr Z; Lavie L;Lavie P. Decreased pituitary-gonadal secretion in men withobstructive sleep apnea. J ClinEndocrinolMetab 2002; 87:3394–3398. 4
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