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Biomimetic Nanoparticles for Targeted Drug Delivery and Toxin Neutralization
Thailand (IFMSA-Thailand) - Faculty of Medicine, Songkla University, Songkhla
Institute of Biomedical Engineering
Assoc. Prof. Puttisak Puttawibul
Dr. Soracha Thamphiwatana
Type of Research Project
- Basic science
What is the background of the project?
We develop biomimetic nanoparticle platform for several therapeutic applications including targeted drug delivery, toxin neutralization, for the treatment of infection and cancer. In this project, we focus on antibiotics-loaded polymeric nanoparticles with biomimetic membrane coating for the treatment of antibiotic-resistant Staphylococcus aurous infection. This nanoparticle platform has dual functions to 1) controlled release antibiotics as well as 2) neutralize pore-forming toxin released from “superbug”, bacteria Staphylococcus aurous. The goal of proposed project is to successfully engineer new therapeutic platform that mimic natural cell membrane for the treatment of infection. The specific aims are as following: 1) formulate nanoparticles loaded with antibiotics and coated with plasma membrane; 2) characterize these nanoparticles; 3) study drug release profile; 4) test antibacterial activity; and 5) validate toxin neutralization.
What is the aim of the project?
The goal of proposed project is to successfully engineer new therapeutic platform that mimic natural cell membrane for the treatment of infection. The specific aims are as following: 1) formulate nanoparticles loaded with antibiotics and coated with plasma membrane; 2) characterize these nanoparticles; 3) study drug release profile; 4) test antibacterial activity; and 5) validate toxin neutralization.
What techniques and methods are used?
The project began in December 2016. Now we successfully synthesize nanoparticles. These nanoparticles will be characterized via scanning electron microscope, size measurement by dynamic light scattering. For in vitro investigation, the techniques are hemolysis assay for toxin neutralization, antibacterial assay, and cytotoxicity assay
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student should be able to perform nanoparticle synthesis. After nanoparticles preparation, the student will learn all characterization techniques including size measurement with dynamic light scattering using Malvern zetasizer; surface morphology using scanning electron microscope; fluorescence intensity measurement and imaging using fluorescence microscopy. Moreover, the student will learn cell culture and bacteria culture techniques as well as hemolysis activity assay and antibacterial assay.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Wang F.; Gao W.; Thamphiwatana S.; et al.; Hydrogel Retaining Toxin-Absorbing Nanosponges for local treatment of Methichillin-Resistant Staphylococcus aureusinfectionAdvanced Materials: 2015 Jun 1; 27(221:3437-43)
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