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The role of protein phosphatase 2A for regulation of signaling in the normal and failing heart
Germany (bvmd) - Martin-Luther-Universitaet Halle-Wittenberg, Halle a.d.Saale
Institute for Pharmacology and Toxicology, Magdeburger Str. 4, 06112 Halle/Saale, Germany
Prof. Dr. Joachim Neumann
Dr. Ulrich Gergs
Type of Research Project
- Basic science
What is the background of the project?
Protein phosphatase 2A (PP2A) is a central cardiac protein phosphatase that regulates a variety of cardiac processes including excitation-contraction coupling, Ca2+ handling, cell metabolism, myofilament regulation, and cell-cell communication. Moreover, current findings support the important role of protein phosphatases in both health and disease, for example by modulation of adrenergic signaling. Tight regulation of PP2A expression and activity is necessary to maintain its physiological function and aberrations in this regulation may contribute to cardiac pathophysiology. In this way, the role of cardiac microRNAs (miRNAs) appears as interesting objective to be investigated because they are small non-coding RNAs, which are involved in a wide range of biological processes by post-transcriptionally regulating the expression of protein-coding genes.
What is the aim of the project?
Identification of differentially expressed miRNAs in hearts of PP2A overexpressing mice and characterization of their role for PP2A-dependent signal transduction.
What techniques and methods are used?
- Isolating mouse cardiac cells and preparations for further examinations - Western blotting - RT PCR (reverse transcription polymerase chain reaction) and real time RT-PCR
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- • Human 5-HT4 receptor stimulation in atria of transgenic mice by U. Gergs et al.
- • Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium by U. Gergs et al.
- • Cardiac overexpression of the human 5-HT4 receptor in mice by U. Gergs et al.
- • Evidence for a functional role of calsequestrin 2 in mouse atrium by U. Gergs et al.
- • Overexpression of the Catalytic Subunit of Protein Phosphatase 2A Impairs Cardiac Function by U. Gergs et al.
- • Modulation of cardiac contractility by serine/threonine protein phosphatase type 5 by U. Gergs et al.
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