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Physiologic function of spontaneous gastrointestinal and urogenital smooth muscle motility
Korea (KMSA) - Chungbuk University, Cheongju
Department of Physiology
Type of Research Project
- Basic science
What is the background of the project?
This course is for the medical student such as have interest about physiological function of our body and organs. Gastrointestinal(GI) and urogenital motility is regulated by pacemaker cell called interstitial cells of Cajal(ICC). They are also regulated by many kinds of ion channels, intrinsic and extrinsic factors including hormones. Therefore, applicants will have a chance to study how these organs and our body doing function by each regulatory factor under physiological study.
What is the aim of the project?
Physiological study is not dissociated course with general medical physiology. Therefore, this course is absolutely based on the text book. This means applicants will study the mechanism of gastric function during digestion; urogenital function such as uterine relaxation and contraction during pregnancy and labor and so on (and/or mechanism of micturition by bladder) Applicants will study the function of each target in contractile study and finally they will chase it in molecular and immunohistochemical study using western blot and confocal microscopy in tissue and cell level.
What techniques and methods are used?
1. Preparing experimental tools need for electrophysiological study ex: silicon plate, glass capillary modification, grinding surgical tools and so on. 2. Training for handling murine stomach, bladder, uterus; human stomach and vessel - Handling tissue and tie each sample for mechanical recording of isometric contraction_ 3. Brief paper work: Study of physiological function of smooth muscle contractility by specific target 4. Evaluation of molecular target which we found in contraction study 5. Elucidation of molecular by confocal microscope using Immuno-fluorescence & histochemical reaction 6. Learning technique of presentation
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1. making own experimental too by supervision 2. Handling tissue and tie by supervision 3. Recording of muscle contractility and check the effect of target function by paper work and supervision 4. Elucidation of target protein by molecular and immunofluorescent study in tissue and cell_5. Learning technique of presentation.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
NONE This course is not hard course to challenge. Now I am teaching our premedical student for 2 semester from last year. It is interesting and useful course for medical student.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
This course is not hard to challenge. Any special skills are not needed.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Song et al.; Diabetes-induced colonic slow transit mediated by the up-regulation of PDGFRα+ cells/SK3 in streptozotocin-induced diabetic mice. Neurogastro enterol Motil.2018
- Meng et al.; H2 S-induced gastric fundus smooth muscle tension potentiation is mediated by the phosphoinositide 3-kinase/Akt/endothelial nitric oxide synthase pathway. Exp Physiol. 2017;102:779 -790
- Kyeong KS et al.; Myometrial relaxation of mice via expression of two pore domain acid sensitive K(+) (TASK-2) channels. Korean J Physiol Pharmacol. 2016; 20(5): 547-56
- Hong SH et al.; Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse. J Vet Med Sci. 2016 1;78(7):1153-9
- Kim YC et al.; Voltage-dependent Ca Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach. Korean J Physiol Pharmacol. 2008 12(6):323-30.
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